Antipsychotics Flashcards Preview

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Flashcards in Antipsychotics Deck (42):
0

Typical antipsychotics

Phenothiazine (-azine)
Butyrophenone (haloperidol)
Thioxanthene (thiothixene)

1

Atypical antipsychotics

Heterocyclics (-pine, -done, -azole)
Clozapine, Olanzapine, Loxapine, Quetiapine
Risperidone, Ziprasidone
Aripiprazole

2

Typical antipsychotic with less EPS but more H1, a1 and muscarinic blockade

Low potency

3

Typical antipsychotic with more EPS but less H1, a1 and muscarinic blockade

High potency

4

Blockade of what dopaminergic receptor is correlated with EPS

D2

5

Location of D2 receptors

Caudate, Putamen, Nucleus accumbens, Cortex, Hypothalamus

6

Dopaminergic tracts associated with schizophrenia

Mesocortical-Mesolimbic
Nigrostriatal
Tuberoinfundibular

7

Treats positive symptoms of schizophrenia

Typical and Atypical antipsychotic

8

Treats negative symptoms of schizophrenia

Atypical antipsychotics

9

Endocrinologic effect of dopamine receptor blockade

Hyperprolactinemia

10

Acute dystonia DOC

Diphenhydramine

11

Parkinsonism DOC

Benztropine

12

Rabbit Syndrome DOC

Benztropine

13

Neuroleptic Malignant Syndrome DOC

Dantrolene

14

Typical antipsychotic MOA

Blocks D2 receptors >> 5HT receptors
Alpha 1 adrenoreceptor blockade

15

Atypical antipsychotic MOA

Blocks 5HT receptors >> D2 receptors

16

Antipsychotic which causes neuroleptic malignant syndrome

Chlorpromazine and Haloperidol

17

Corneal and lens deposits seen in patients receiving which antipsychotic

Chlorpromazine only

18

Antipsychotic used as antiemetic

Prochlorperazine

19

Retinal deposits seen in patients receiving which antipsychotic

Thioridazine and all other phenothiazine

20

Antipsychotic with fatal overdose

Thioridazine

21

Antipsychotic with strongest autonomic effects

Thioridazine

22

Antipsychotic used for Tourette syndrome

Haloperidol or Risperidone

23

Antipsychotic used for Huntington's disease

Haloperidol

24

Antipsychotic with weakest autonomic effect

Haloperidol

25

Antipsychotic that reduces suicide risk in schizophrenics

Clozapine

26

Antipsychotic causing marked weight gain, hyperlopodemis, hyperglycemia

Olanzapine

27

Antipsychotic drug for anorexia nervosa

Olanzapine

28

Quetiapine side effects

Somnolence, sleep paralysis, hypnagogic hallucinations and priapism

29

Antipsychotic for youth schizophrenia

Risperidone

30

Antipsychotic for intractable hiccups

Risperidone

31

Antipsychotic causing photosensitivity

Risperidone

32

Antipsychotic causing QT prolongation

Ziprasidone

33

Least sedating typical antipsychotic

Haloperidol

34

Least sedating atypical antipsychotic

Aripiprazole

35

Patient on Chlorpromazine develops fever, unstable VS, rigidity and disorientation. Labs show elevated CPK. DOC?

Dantrolene (neuroleptic malignant syndrome)

36

Bipolar Disorder DOC

Lithium

37

T/F: antidepressant monotherapy is the DOC for bipolar disorder

False. Antidepressant + Lithium (manic episodes)

38

Mood stabilizer contraindicated in sick sinus syndrome

Lithium

39

Teratogenic effect of Lithium

Ebstein anomaly

40

Lithium overdose treatment

Hemodialysis

41

Toxicity threshold for Lithium

2 meq/L