Antimicrobials Flashcards Preview

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Flashcards in Antimicrobials Deck (24):
1

B-Lactams

2

Glycopeptides

3

Bacitracin

4

Cycloserine

5

Phosphonomycin

Process Targeted: Cell wall synthesis

Mechanism of Action: Inhibits NAM synthesis

Drug Inactivation: None

Altered Drug target: Rare

Altered Drug uptake: rare

6

Isoniazid

7

Ethambutol

8

Lipopeptides 

Process targetedL Cell membrane integrity

Mechanism: Destabilizes Gram-positive cell membranes

Drug Inactivation: none

Altered Drug target: None

Altered Drug uptake: none 

Other resistance: unknown

9

Aminoglycosides

Process Targeted: Translation

Mechanism: Binds 30S ribosomal subunit near A site

Drug Inactivation: APH, AAC, ANT

Altered Drug target: Rare

Altered drug uptake: Altered membrane potential

Other Resistance: None 

10

Tetracyclines

11

Macrolides

12

Lincosamides

13

Streptogrammins

Process targeted: Translation 

Mechanism: B-subunit binds 50S ribosome subunit blocking exiting peptide

Drug Inactivation: VGB

Altered Drug target: rRNA methylation

Altered drug uptake: Gram-positive efflux 

Other resistance: none

14

Oxazolidinones

15

Fusidic Acid

16

Mupirocin

17

Quinolones

18

Rifamycins

19

Sulfonamides

20

Trimethoprim

21

Diarylquinolines

22

Nitrofurantoin

Process: Prodrug

Mechanism: Activated by nitroreductases to relase reactive nitrogen intermediates (RNI)

Drug inactivation: None

23

Metronidazole

Process: prodrug

Mechanism: Activated by nitroreducates to release RNIs

Drug inactivation: none

Altered drug target: Loss of nitroreductase

Altered drug uptake: none

24

Pyranzenamide

Process: prodrug

Mechanism: unknown

Drug inactivation: none

Altered Drug target:altered PncA

Altered drug uptake: none