Antiviral Chemotherapy & Prophylaxis Flashcards Preview

Pharmacology 1 > Antiviral Chemotherapy & Prophylaxis > Flashcards

Flashcards in Antiviral Chemotherapy & Prophylaxis Deck (28):
0

Antiviral MOA: activated by viral thymidine kinase to form that inhibit viral DNA polymerase

Use: HSV-1, HSV 2, VZV

Acyclovir

1

DOC: CMV
SE: leukopenia

Gancyclovir

2

Antiviral Use: CMV retinitis, molluscom contagiosum (umbilicated papule)

Cifodovir

3

Antiviral MOA- inhibits viral RNA polymerase, DNA polymerase & HIV reverse transcriptase, bind to pyrophosphate binding site
Use: CMV retinitis, HSV infection w/ AIDS
Active against strains of HSV w/ absent thymidine kinase activity

Foscarnet

4

Class: nucleoside reverse transcriptase inhibitor
MOA: inhibit HIV reverse transcriptase after phosphorylation by cellular enzymes
Use: HIV, prevention of maternal fetal HIV transmission

Zidovudine
Abacavir, didanosine, lamivudine, stavudine

5

Zidovudine SE

Lactic acidosis, bone marrow supression

6

Abacavir SE:

Hypersensitivity

7

Didanosine SE:

Pancreatitis

8

Stavudine, Zalcitabine SE:

Peripheral neuropathy

9

Class: non-nucleoside reverse transcriptase inhibitor
MOA: inhibit HIV Reverse transcriptase No phosphorylation required

Delavirdine, eravirenz, etravirine, nevirapine

10

Delavirdine, neviraline SE:

Rash, increased AST/ALT

11

Efavirenz SE:

Teratogenicity

12

Etravirine SE:

Increased cholesterol, triglycerides

13

Nonnucleoside reverse transcriptase inhibitor (NNRTI)

Never Ever Deliver Nucleosides
Nevirapine
Efavirenz
Delavirdine

14

Class: Protease inhibitor
MOA: inhibit viral protein processing
Use: HIV infection
SE: hyperlipidemia, fat redistribution, hyperglycemia, insulin resistance

Indinavir

15

Saquinavir SE

GI distress & diarrhea

16

Atazanavir SE:

Peripheral neuropathy

17

Amprenavir SE

Rash

18

Indinavir SE

Hyperbilirubinemia & nephrolithiasis

19

Class: fusion inhibitor
MOA: binds to gp41 subunit of viral envelope glycoprotein, preventing fusion of viral and cellular membranes

Enfuvirtide

20

Class: CCR5 receptor antagonist

Maraviroc

21

Class: anti-influenza
MOA: inhibit early step replication and prevent uncoating by binding to M2 proton channels
Use: influenza A only, rubella

Amantidine

22

Amantadine SE:

Livido reticularis
Cerebellar dysfunction

23

Class: anti-influenza
MOA: inhibits neuraminidase. Decrease release of progeny virus
Use: influenza A and B, shortens duration of symptoms

DOC for influenza ( includ H1N1)

Oseltamivir

24

Oseltamivir SE:

GI effects

25

Zanamivir SE:

Bronchospasms

26

Class: interferon
MOA: degrades viral RNA via activation of host cell RNAase
Use: HBV, HBC, Kaposi

Interferon alpha

27

MOA: inhibits guanosine triphosphate formation. Prevents capping of viral mRNA. Blocks RNA-dependent RNA polymerase
Use: HCV, RSV

Ribavirin