ART regimens Flashcards
Name appropriate regimen of kids with respect to age and body mass
Age: 0 to younger than 4 weeks (2kg)
Zidovudine (AZT)+Lamivudine(3dT)+Nevirapine(NVP)
Age: 4 weeks or older than that, but less than 10 years. (>/=3 kg)
Abacavir(ABC)+Lamivudine(3dT)+Dolutegravir
Age: 10 years going up(>/=30kg)
Tenofovir+Lamivudine+Dolutegravir
What is the preferred first line regimen?
TLD- Tenofovir+Lamivudine+Dalutegravir
What is the alternative 1st regimen for patients with TB?
TEE- Tenofovir+Emtricitabine+Efavirenz
What is the alternative 1st line regimen for pregnant women in <6 weeks gestation or actively wanting to conceive?
TEE- Tenofovir+Emtricitabine+Efavirenz
If women cannot tolerate Efavirenz, subtitute it with Dolutegravir. New regime
TED
If there are contraindications against both Efavirenz and Dolutegravir, use Lopinavir
Which drugs to use if there is a contraindication against tenofovir on the preferred 1st line regimen?
Zidovudine or Abacavir
What’s the 2nd line regimen for ART?
Zidovudine (AZT)+Lamivudine (3dT)+Dolutegravir (DTG)
*ZLD
Must replace AZT with Tenofovir (TDF) in presence of HepB surface antigens.
Or replace both AZT and TDF with ABC on contraindications
Replace Dolutegravir with Lopinavir in contraindications.
Also replace that lopinavir with atazanavir if lopinavir cause dsylipidaemia or diarrhoea
What is the approved regimen for PrEP?
Tenofovir+ Emtricitabine
*The 2 drugs are combined into 1 pill called Truvada
What is the approved regimen for PEP (a 28 day treatment)?
Tenofovir+ Lamivudine+ Dolutegravir (TLD)
*similar to the approved first line regimen
Subtitute Tenofovir with Zidovudine if there are contraindications
Subtitute dolutegravir with either Lopinavir or Atazanavir if there are contraindications
ART regimen for HIV/TB coinfection should be based on what drug/agent?
Efavirenz
*Plasma levels of EFZ are not reduced by rifampicin, which is a drug constituting TB regimen
