Arthritis and Gout Drugs Use and Side effects Flashcards Preview

Pharm Unit 2 MJC > Arthritis and Gout Drugs Use and Side effects > Flashcards

Flashcards in Arthritis and Gout Drugs Use and Side effects Deck (22)
1

Indomethacin

Use: rheumatoid arthritis; acute gouty arthritis

SE: gastric and duodenal ulcers

2

Naproxen

Use: Rheumatoid arthritis and acute gouty arthritis

SE: Gastric and duodenal ulcers

3

COX-2 inhibitors

Use: Superseding conventional NSAIDS for rheumatoid arthritis

SE: 50% fewer gastric and duodenal ulcers

4

Quinolones

Use: Rheumatoid arthritis, SLE

SE: Retinal damage

5

Glucocorticoids

Use: Rheumatoid arthritis; acute gouty arthritis (intraarticular injection for relief of acute monoarticular gout)

SE: Cushing symptoms

6

Sulfasalazine

Use: Rheumatoid arthritis

SE: N/V, skin rashes, neutropenia (30% of patients discontinue) headaches

7

Methotrexate

Use: Rheumatoid arthritis

SE: Nausea, stomatitis, hepatotoxicity (rare)

8

Leflunomide

Use: Rheumatoid arthritis

SE: Diarrhea, hepatotoxicity

9

Etanercept

Use: Rheumatoid arthritis

SE: none

10

Infliximab

Use: Rheumatoid arthritis

SE: Antigenic response to mouse Ab

11

Adalimumab

Use: Rheumatoid arthritis

12

Golimumab

Use: Rheumatoid arthritis

SE: Risk of infections

13

Certolizumab

Use: Rheumatoid arthritis

SE: Risk of infections

14

Anakinra

Use: Rheumatoid arthritis

15

Tocilizumab

Use: Rheumatoid arthritis

16

Rituximab

Use: Rheumatoid arthritis

SE: Infections; hypersensitivity reactions

17

Abatacept

Use: Rheumatoid arthritis

SE: Headaches and infections

18

Colchicine

Use: Acute gouty arthritis

SE: Low therapeutic index, long term use causes peripheral neuropathy and neutropenia. Nausea vomiting and toublesome diarrhea

19

Probenecid

Use: Chronic tophaceous gout

SE: Urate crystal mobilization and acute gouty arthritis and GI irritation

20

Allopurinol

Use: Chronic tophaceous gout

SE: Acute attacks of gouty arthritis early in treatment due to mobilization of crystals

21

Febuxostate

Use: Chronic Tophaceous gout

SE: Nausea, rash, arthralgias

22

Pegolitcase

Use: Chonic tophaceous gout