Atherosclerosis

Question 1

Atherosclerosis

Answer 1

Chronic inflammatory disease of the inner layer (tunica intima) or arteries. Causes narrowing and hardening of arteries due to lipid garbage from fibrosis.

Question 2

Atherosclerotic CV disease is the most common cause of death in US

Answer 2

true

Question 3

What size arteries does atherosclerosis prefer?

Answer 3

medium and large

Especially coronary, cerebral, aorta

Question 4

Step one of atherosclerotic injury

Answer 4

injury to the endothelial cells causes cytokine release, increased permeability,

Question 5

Step two

Answer 5

accumulation of lipid (LDL) which is trapped by proteoglycans in the ECM who’se production increases in hypertension.

Question 6

Step 3

Answer 6

Leukocyte recruitment to teh tunica intima and smooth muscle cells which turn into phagocytes

Question 7

Step 4

Answer 7

Foam cell formation, macrophages phagocytose modified LDL

Question 8

Step 5

Answer 8

ECM deposition and collagen deposition.

Question 9

Earleist visible pathology

Answer 9

fatty streaks

Question 10

What do atheromatous plaques look like?

Answer 10

soft yellow core called atheroma with a white fibrous cap.

Question 11

Thrombosis superimposed on atherosclerosis

Answer 11

BAD

Question 12

Three factors predispose to thrombosis

Answer 12

endothelial injury, hypercoagulability, abnormal blood flow