Flashcards in Miscellaneous drugs Deck (10)
What is pheochromocytoma and what is it treated with?
Pheochromocytoma is a tumor of the adrenal gland and leads to too much catecholamine production. Treated with drugs like Metyrosine which block tyrosine hydroxylase, the rate limiting enzyme of catecholamine synthesis. This reduces epinephrine and norepinephrine concentrations and alleviates attacks of HTN.
Autoreceptors vs Heteroreceptors
Autoreceptors= feedback inhibition, example is Alpha 2 receptor which takes in norepinephrine and prevents more presynaptic vessicles from being made and thus, more NE from being released.
expression of cholinergic receptor (alpha 2)on non-cholinergic tissue. Alpha 2 agonists can activate theses heteroreceptors and it leads to bradycardia, hypotension, analgesia, etc...
Alpha 2 agonists
Inhibit sympathetic tone and lower BP
Alpha 2 agonists that cannot penetrate the blood brain barrier do not effectively lower BP.
Major use of alpha 2 agonists
Useful in preventing reflex tachycardia.
Why are these drugs useful in diabetics and asthmatics
No meaningful effect on blood glucose or lung function
Somnolence, Dry Mouth,
Reserpine does what?
Binds tightly to adrenergic storage vesicles in central and peripheral adrenergic neurons. It inhibits the catecholamine transporter. No storage of NE and Dopamine.