Vasculitis and Complications of MIs Flashcards Preview

Cardio Block > Vasculitis and Complications of MIs > Flashcards

Flashcards in Vasculitis and Complications of MIs Deck (55)
Loading flashcards...
1

Two divisions of vasulitis

Infectious and non-infectious (primary)

2

Predominant fungal cause of infectious vasculitls

Aspergillus

3

Predominant bacterial cause of IV

Cytomegalovirus

4

Predominant bacterial cause

Psuedomonas

5

Pathophysiology of Primary Vasculitis

Dendritic cells int eh tunica adventitia go haywire and instead of disposing of self-recognizing immune cells they activate them. These immune cells then degrade the elastic lamina
Another mechanism.... Immune complex deposition. Inflammation mediated by complement, chemoattractants, neutrophils, lysosomal enzymes, free radicals.

6

Major signs and symptoms

palpable purpura and fever

7

Hypersensitivity angiitis

acute necrotizing inflammatory disease of the smallest vessels (arterioles, cappilaries, venuoles). Usually in the skin

8

Cutaneous hypersensitivity angiitis also referred to as?

Leukocytoclastic vasculitis

9

10% of cases of hypersensitivity angiitis due to?

drugs

10

What drugs?

Quinolones, penicillins, sulfonamides, Retinoids, etc...

11

Microscopic polyangiitis is

hypersensitivity angiitis involving internal organs

12

Pathogenesis of hypersensitivity angiitis?

immune complex deposition and complement activation 7-10 days after exposure to an antigen (drug)

13

Pathology of hypersensitivity angiitis

infiltration of vessels by neutrophils, later lymphocytes

14

Diagnosis requires?

biopsy

15

Signs

palpable purpura

16

Treatment

stop the drug, treat the infection, excise the tumor...etc...
If it infects the organs, treat with immunosuppresive therapy

17

Temporal arteritis

Giant cell arteritis, granulomatous inflammatory disease of medium and larger arteries, esp in the head

18

Temporal arteritis common

Fairly...1 in 750 over the age of 50, female predominance, more common in whites

19

Temporal arteritis autoimmune?

yep

20

Pathology of temporal arteritis

multinucleated giant cells destroy internal elastic lamina. Transmural granulomatous inflammation. Intimal thickening, cell proliferation and luminal stenosis

21

Signs and symptoms

headache, visual disturbance, jaw claudication, swollen tender artery.
Fever malaise and wt loss make blindness less likely

22

Polymyalgia rheumatica

chronic autoimmune inflammatory disease of muscle. Temporal arteritis is associated with it in 40% of cases.

23

Complcations of temporal arteritis

blindness, aortic aneurysm, arterial dissection, arterial rupture

24

Temporal arteritis is diagnosed by

ESR and biopsy

25

Treat temporal arteritis with

steroids

26

Temporal arteritis

old white women

27

Kawasaki disease

mucocutaneous lymph node syndrome...vasculitis of medium arteries, especially coronaries.

28

kawasaki predominantly effects who>

children 1-2 yrs of age, males, japanese

29

Kawasaki complications

arterial rupture, MI, death

30

Pathogenesis

An immune reaction to an RNA virus