Ganglionic Blockers Flashcards Preview

Cardio Block > Ganglionic Blockers > Flashcards

Flashcards in Ganglionic Blockers Deck (9)
Loading flashcards...
1

Ganglionic blockers refers to what?

Antagonists of cholinergic nicotinic receptors found on autonomic ganglia.

2

One drug

trimethaphan

3

Ganglionic blockers have widespread effects on the entire body

True...that's why they have been replaced as HTN drugs

4

main neurotransmitter in sympathetic and parasympathetic ganglia

acetylcholine

5

Effect of ganglionic blockade on arterioles

Vasodilation; increased peripheral blood flow, hypotension
This is predominantly innervated by sympathetics so this makes sense

6

Effect of ganglionic blockade on veins

Dilation, peripheral pooling of blood; decreased venous return, decreased cardiac output

7

Heart

tachycardia
Predominantly causes cholinergic blockage

8

Mech of action

compete with ach for nicotinic binding site. Block the initial EPSP caused by big Na release and leads to inhibition of ganglionic transmission

9

Adverse effects

hypotension, tachycardia, arrhytmia, blurred vision, asthma, dry mouth, constipation, urinary retention