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Flashcards in B vitamins Deck (21):
1

What is the other name for B1?

Thiamine

2

What kind of enzymes use thiamine?

Dehydrogenase enzymes (B3 is more often seen with these enzymes)

3

What is seen with thiamine deficiency?

Wernicke-Korsakoff syndrome (confusion + ophthalmoplegia + ataxia)
Dry beriberi (polyneuritis + symmetrical muscle wasting)
Wet beriberi (high-output cardiac failure + edema)

4

What is the concern of giving glucose to thiamine deficient patients?

Can damage mammillary bodies...GIVE THIAMINE FIRST

5

What is the other name for B2? What kind of reactions use B2?

Riboflavin (FMN/FAD)

Carboxylation/Decarboxylation

6

What is seen with riboflavin deficiency?

Cheilosis
Corneal vascularization

7

What is the other name for B3?

Niacin (NAD/NADP)

8

What is seen with niacin deficiency?

Diarrhea
Dementia
Dermatitis

9

What is the other name for B5?

Pantothenate (CoA)

10

What is seen with pantothenate deficiency?

Dermatitis, enteritis, alopecia, adrenal insufficiency

11

What is another name for B6?

Pyridoxine

12

What enzymes use pyridoxine?

Transamination enzymes

13

What is seen with pyridoxine deficiency?

Convulsions, hyperirritability, peripheral neuropathy, sideroblastic anemias

14

What is another name for B7?

Biotin

15

What enzymes use biotin?

Carboxylation enzymes

16

What weird dietary substance can cause biotin deficiency?

Raw egg whites...avidin in egg whites binds biotin

17

What is another name for B9?

Folic Acid

18

You better not screw up on a folic acid question...

Or a B12 question for that matter

19

What is the other name for B12?

Cobalamin

20

Patient comes in and after labs it is determined that she has megaloblastic anemia. So she is given folic acid and B12. She comes in a week later and still has megaloblastic anemia. What is likely elevated in her serum?

Orotic aciduria (d/t defect in UMP synthase) presents with megaloblastic anemia and elevated orotic acid

21

Besides orotic aciduria, what else can present with elevated orotic acid? How can these two diseases be distinguished from each other?

Ornithine Transcarbamylase Deficiency (part of urea cycle) presents with hyperammonemia, but NOT megaloblastic anemia

(this makes sense knowing that orotic aciduria is a deficiency in a pyrimidine synthesis and ornithine transcarbamylase deficiency is urea cycle)