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Flashcards in Immuno drugs Deck (32):
1

What is the MoA of cyclosporine?

Cyclosporine binds cyclophlin → inhibition of calcineurin → no IL-2 transcription → blocked T cell activation

2

What are the toxicities of cyclosporine?

NEPHROTOXICITY
Hypertension
Hyperlipidemia
Hyperglycemia
Tremor
Hirsutism
Gingival hyperplasia

3

What is the MoA of tacrolimus?

Binds FKBP → inhibition of calcineurin → no IL-2 transcription → blocked T cell activation

Notice: after the initial step this is the same as cyclosporine

4

What toxicities that ARE seen with cyclosporine are NOT seen with tacrolimus?

No gingival hyperplasia or hirsutism

5

What is the MoA of sirolimus (rapamycin)?

Binds FKBP → inhibits mTOR → no IL-2 signal transduction → blocked T cell activation and B cell differentiation

6

What toxicities are seen with sirolimus?

Anemia/thrombocytopenia/leukopenia
Insulin resistance
Hyperlipidemia

NON-NEPHROTOXIC

7

What is basiliximab an Ab to?

IL-2R

8

What is azathioprine?

Antimetabolite precursor of 6-MP

9

How do glucocorticoids suppress the immune system?

Glucocorticoids inhibit NF-kB → decreased tsx of many cytokines

10

How is NF-kB activated? What does it usually do?

NF-kB is phosphorylated, and then ubquinated → proteosomal cleavage to active form → tsx regulator

11

What is oprelvekin?

IL-11...used with thrombocytopenia

12

What can be used for the recovery of bone marrow?

Filgrastim (Granulocyte Colon-Stimulating Factor...G-CSF)
Sargramostim (GM-CSF...Granulocyte-Macrophage Colony-Stimulating Factor)

13

What is aldesleukin? When is it used?

IL-2

Used in Renal Cell Carcinoma and metastatic melanoma

14

When is IFN-α used?

Chronic HBV/HCV
Kaposi sarcoma
Hairy cell leukemia
Condyloma acuminatum
Renal cell carcinoma
Malignant melanoma

15

When is IFN-β used?

Multiple Sclerosis

16

When is IFN-γ used?

Chronic granulomatous disease

17

What are some therapeutic antibodies used for various cancers?

Alemtuzumab
Bevacizumab
Cetuximab
Rituximab
Trastuzumab

18

Alemtuzumab?

CD52

CLL

19

Bevacizumab?

VEGF

CRC and RCC

20

Cetuximab?

EGFR

Stage IV CRC and head/neck cancer

21

Rituximab?

CD20

Non-Hodgkin lymphoma, rheumatoid arthritis (w/ MTX), ITP

22

Trastuzumab?

HER2/neu

Breast cancer or gastric cancer

23

What are some therapeutic antibodies used for autoimmune diseases?

Infliximab, adalimumab
Natalizumab

24

Infliximab, adalimumab?

TNF-α

IBD, RA, ankylosing spondylitis, psoriasis

25

Natalizumab?

α4-integrin (leukocyte adhesion)

MS, Crohn disease

26

What are some other therapeutic antibodies?

Abciximab
Denosumab
Digoxin immune Fab
Omalizumab
Palivizumab
Murmonab-CD3 (OKT-3)

27

Abciximab?

GpIIb/IIIa

28

Denosumab?

RANKL

Osteoporosis (remember...RANKL causes the activation of osteoclasts)

29

Digoxin immune Fab?

Digoxin overdose

30

Omalizumab?

IgE

Allergic asthma

31

Palivizumab?

RSV F protein

RSV prophylaxis for high-risk infants

32

Murmonab-CD3 (OKT3)?

CD3

Prevent transplant rejection