Wound healing Flashcards Preview

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Flashcards in Wound healing Deck (18):
1

What facilitates leukocyte margination and rolling?

Selectins (on both vasculature and leukocyte)
Sialyl-Lewis (on leukocyte...no idea what this is...don't really care)

2

What facilitates tight binding between the vasculature and leukocytes?

ICAM and VCAM (vasculature)
Integrins...like CD18 (leukocyte)

3

What facilitates diapedesis (transmigration) of the leukocyte through the vasculature?

PECAMs (on both vasculature and leukocyte)

4

What guides leukocytes to the site of the injury after entering the interstitium?

Chemotactic signals (C5a, IL-8, LTB4, kallikrein, platelet-activating factor)

5

Where does leukocyte extravasation usually occur?

Postcapillary venules

6

What are the two kinds of possible scar formations?

Hypertrophic scars (normal)
Keloid scars (look like an ugly tumor)

7

What secretes PDGF? What does PDGF do?

PDGF is secreted by activated platelets and macrophages

It induces vascular remodeling and smooth muscle cell migration
It also stimulates fibroblast growth for collagen synthesis

8

What does FGF do?

Stimulates all aspects of angiogenesis

9

What does EGF do?

Stimulates cell growth via tyrosine kinases (like EGFR...as expressed by ERBB2)

10

What does TGF-β do?

Angiogenesis, fibrosis, cell cycle arrest

11

What do metalloproteinases do?

Tissue remodeling

12

What are the three phases of wound healing?

Inflammatory (immediate)
Proliferative (2-3 days post injury)
Remodeling (1 week post injury)

13

What mediates the inflammatory phase?

Platelets
Neutrophils
Macrophages

14

What happens during the inflammatory phase?

Clot formation
Increased vessel permeability and neutrophil migration
Macrophages clear debris 2 days later

15

What mediates the proliferative phase?

Fibroblasts, myofibroblasts, endothelial cells, keratinocytes, macrophages

16

What happens during the proliferative phase?

Deposition of granulation tissue and collagen
Angiogenesis
Epithelial cell proliferation
Dissolution of clot
Wound contraction (mediated by myofibroblasts)

17

What mediates the remodeling phase?

Fibroblasts

18

What happens during the remodeling phase?

Type I collagen replaces type III collagen → increased tensile strength