Basic Cellular Rxns to CNS Injury - Glial cells and shit Flashcards Preview

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Flashcards in Basic Cellular Rxns to CNS Injury - Glial cells and shit Deck (14):
1

Neuropil

Background on slide but most important part, where 99% of all synapses are

2

Nissl Bodies

RER that make proteins to be sent out (like neuropeptides)

3

Axonal Reaction (Central Chromatolysis)

Following injury - more ribosomes for internal production, not Nissl bodies bc don't want external. Nuc falls to edge and loses color

4

PNS vs. CNS Axonal Regeneration

Can vs. can't. Schwann cells aid

5

Eosinophilic Nerve Cell Change

From destructive injury/necrosis

6

Simple (chronic) Atrophy

Shrinks and works at reduced capacity. Remove insult and can recover almost 100%

7

Main Diff of Human Brains (from others)

Astrocytes have shitload more processes

8

Reactive (Gemistocytic) Astrocytes

Get hypertrophic when damage done to CNS

9

Two Ways Astrocytes Prevent Cell Death on Edge of Ischemia

Release GFs that tell cells to live and eat toxins coming in from necrotic area

10

4 Beneficial Aspects of Reactive Astrocytes

Restore ionic homeostasis
Remove glutamate
Release GFs
Restore BBB

11

3 Potential Negative Effects of Reactive Astrocytes

May interfere w/ neurite outgrowth, block remyelination, or contribute to seizure focus

12

Alzheimer Type II Astrocyte

NOT ASSOCIATED W/ AD. Large vacuolated astrocyte from metabolic insult to NS (not destructive) like from liver disease. Don't work so then effects can also affect neurons

13

Gitter Cells

CNS macs, activate and signal for blood monocytes to join (BBB gets leakier)

14

Choroid Plexus Transformation

Ependymal cilia change to microvilli, look like kidney epithelial cells