Blood Lecture 1 / Ch 6 White blood cells Flashcards Preview

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Flashcards in Blood Lecture 1 / Ch 6 White blood cells Deck (36):
1

Leukocytes


• Identify and attack foreign
material (Antigens)

2

All WBC originate from ?

stem Cells in Hematopoietic bone marrow

3

Most WBC circulate within?

vascular and lymphatic systems

4

Number of WBC

4,500 - 11,000 WBC / μL

higher at birth

15,000-25,000

5

Leukocytosis

increased WBC count
- classic sign of infection
- sign of leukemia

6

Leukopenia

decreased WBC count
4,500 WBC / μL

– Caused by decreased production (chemo or
radiation therapy)
or increased destruction
(hypersplenism)

7

Types of WBC

• Granulocytes
• Monocytes AKA: Macrophage
• Lymphocytes

8

Granulocytes

- Neutrophils
- Eosinophils
- Basophils

9

Monocytes

- Released from the bone marrow
- Removes dead and damaged cells.
- becomes Macrophage or Histocyte
- Monocyte Exists 1-2 days in circulation

10

Lymphocytes

T cells and B cells

11

Chemotaxis

WBC respond to chemical stimuli (cytokines) using the concentration of the stimuli
to direct its movement to the site of inflammation

12

Diapedesis

Movement through capillary pores into body tissue

13

Pluripotential Stem Cell >

Myeloid & Lymphoid

14

Vast quantities of _____ _____ reside in the bone marrow as a reserve

immature granulcytes

15

Contain numerous granules in their cytoplasm which contain digestive enzymes.

Granulocytes

16

4 facts of Neutrophils

- Polymorphonuclear leukocytes
- Contain multi-lobed nuclei
- Most abundant WBC
- Ineffective against foreign protein toxins

17

2 Neutrophils Function

- primary phagocytic cell
- sensitive to chemical
attractants

18

Neutrophils Life Span

- 10-12 hours in vascular space
- 5-6 days in tissue

19

Neutrophils Location

- 50% in circulation
- 50% marginate (adhere to
endothelium) many in the
lungs

20

Neutrophils Bands = immature neutrophils in circulation.
Believed to be classic sign of what?

infection (“shift to the left”)

21

Neutrophils in premature
infants are?

Immature and make them more suceptible to bacterial and fungal infections.

22

Neutrophilia

increased number of
neutrophils

23

Neutropenia

decreased number of
neutrophils

24

Eosinophils

Attack foreign proteins, parasites and function in allergic reactions

25

Eosinophils are Weakly phagocytic, they release what ?

Major Basic Protein (MBP) which lyses membranes

26

Eosinophils mature in bone marrow -> they
circulate in the vascular space, then they move to tissue space. What is their total life span?

12-24 hrs

27

Basophils

Mast Cells or Tissue Basophils when found in tissue.

- involved in allergic, anaphylactic & chemotaxis reactions
- Attach to antigen and spew out loads of anaphylatoxins.
(Histamine & Heparin)

28

What organism stays until all antigen is destroyed?

Monocytes, they make up the Reticuloendothelial System (RES).

29

Name the macrophages found In the liver?

kupfer cells

30

Name the macrophages found In the lungs?

alveolar Macrophages

31

Name the macrophages found In the brain?

microglial cells

32

Name the macrophages found In the bone marrow?

dendritic cells

33

Name the macrophages from the GI tract found In the peyers patches?

Peritoneal macrophages

34

Antigen Presenting Cells (APC)

Ingest antigen and present its
surface molocules to antibody producing cells to provide long
term immunity (memory of specific antigens)

35

A white cell count in which bands are detected is called what ?

Shift to the left

36

Dead Neutrofils =

pus