4 Processes that prevent blood loss ?
- ) Vascular Spasm
- ) Platelet plug formation
- ) Coagulation protein activation that leads to clot formation.
- ) Lysis of clot
Endothelial cells of blood vessel walls release specific molecules as a result of vascular injury to assist with platelet aggregation, name 4 ?
- ) Serotonin
- ) Adenosine di-phosphate
- ) von Willebrand Factor
- ) Fibronectin
Capillaries can usually arrest blood loss with what only?
Platelet plug AKA white thrombus
When vascular damage occurs, the ondothelial lining plays a crucial role in hemostasis. Vessel walls release molecules that attach themselves to activated platelets, assist in fibrin clot formation, and are involved with clot dissolution. Endothelial cells produce other chemicals what are they ?
- AT-III = Anticoagulant
- Thrombomodulin = Anticoagulant
- Prostaglandin PGI2 = Clot Inhibitor
- tPA (tissue plasminogen activator) = Fibrinolytic
Name the 5 steps involved in Platelet Plug Formation ?
- ) Contact between platelets and damaged endothelium.
- ) Adhesion
- ) Spreading of platelets along the damaged surface
- ) ADP release
- ) Aggregation
Molecule that binds to certain clotting factors which leads to fibrin clot formation over the platelet plug.
Platelet Factor 3 (PF-3)
Once the fibrin clot has formed, what helps to repair the damaged endothelium ?
- Fibroblasts (Connective tissue cells)
* Endothelial cells
Molecule released by platelet granules that stimulates smooth muscle cells in the vessel wall to advance vessel healing ?
Platelet-derived growth factor
Prostaglandins are molecules that regulate the amount of ADP released by platelets. These molecules work antagonistically to increase or decrease ADP release. What are the 2 most important prostaglandins ?
- Thromboxane A2 (TXA2)
* Prostacyclin (PGI2)
What prostaglandin increases the release of ADP ?
What prostaglandin decreases the release of ADP ?
When blood comes into contact with a foreign surface, platelets aggregate and attach to the surface. When platelets aggregate they release molecules such as what, to initiate clot formation ?
What are the 3 types of thrombocytosis AKA thrombocytopenia that cause an increase in platelet count?