Flashcards in Mix of Study Materials for Blood Test 2 Deck (41)
What is the protein (glue) that vWF recognizes and begins connecting to each other?
GPIb - IX - V
During platelet aggregation what is released ?
During platelet aggregation Fibrinogen connects 2 platelets via what receptors?
GPIIb / IIIa
Liquid plasma treats factor deficiencies for which there is no specific concentrate, such as ?
XI & XII
Cryoprecipitate treats what ?
Immune serum globulins (Gammaglobulins) are generated from what ?
Platelet Poor Plasma
Whole blood centrifuged via 4 degees celcius produces what ?
Platelet Rich Plasma
Packed Red Cells
Platelet Rich Plasma centrifuged via 20 degrees celcius produces what ?
Platelet Poor Plasma
Platelet Poor Plasma frozen down to -70 degrees celcius produces what ?
Factor VIII deficient plasma
Packed Red Cells Frozen down to -80 degrees celcius produces what ?
Frozen red cells
Packed Red Cells produces what ?
Leukocyte poor Red Cells
Platelet Poor Plasma frozen down to -20 degrees celcius provides what ?
Fresh Frozen Plasma with a therapeutic concentration of ATIII.
Can be stored up to 1 year at -18 degrees celcius
Platelet Poor Plasma frozen down to -70 degrees celcius and then THAWED out produces what ?
Systems in place to prevent inappropriate activation of TPA ?
Aplha 2 - Plasmin Inhibitor
Alpha 2 - Macroglobulin
What is the role of Alpha 2 - Antiplasmin ?
Inactivates any plasmin outside of the clot.
Gray platelet syndrome
Platelets cannot adhere to the endothelium
1/3 of platelets are sequestered by the spleen
How does Thromboxane A2 regulate ADP ?
Increases release of ADP synthesized by the platelet membrane.
How does PGI2 regulate ADP ?
Decreases the release of ADP synthesized by the endothelial cells lining the blood vessel.
Transitory Thrombocytosis ?
450k - 600k
Exercise and stress releases sequestered platelets by the lungs and the spleen.
Reactive Thrombocytosis ?
600k - 800k
Caused by increase production in the bone marrow as a result of inflammatory diseases, ect.
Primary Thrombocytosis ?
Caused by myeloproliferative disorder of stems cells.
Treatment for vWF disease?
Desmopressin Acetate = releases stored vWF
Replacement Factor VIII
Coumadin works by?
Inhibits vitamin K dependent factors (II, VII, IX, X, protein C, and protein S). Effect seen 3 - 5 days.
Name 2 Xa Inhibitors ?
ELIQUIS ( apixaban)
Name 5 Direct thrombin Inhibitors ?
1.) Hirudin, R-hirudin
4.) Argatroban (Acova)
Anticoagulants for patients with HIT ?
- delay surgery
- use heparin with protamine reversal during surgery
Hirudin, Lepirudin, or Argatroban.
But the most common used is Bivalirudin.
What else can we give to conteract heparin besides Protamine ?
Polybrene 1 u / mL
How do you calculate INR ?
(Patients PT / Mean Normal Prothrombin Time ) ^ International sensitive Index 1.297