Mix of Study Materials for Blood Test 2 Flashcards Preview

CVPR 330 Blood > Mix of Study Materials for Blood Test 2 > Flashcards

Flashcards in Mix of Study Materials for Blood Test 2 Deck (41):
1

What is the protein (glue) that vWF recognizes and begins connecting to each other?

GPIb - IX - V

2

During platelet aggregation what is released ?

Dense Bodies
Alpha Granules

3

During platelet aggregation Fibrinogen connects 2 platelets via what receptors?

GPIIb / IIIa

4

Liquid plasma treats factor deficiencies for which there is no specific concentrate, such as ?

XI & XII

5

Cryoprecipitate treats what ?

XIII deficiency
vWF disease
Hemophelia A

6

Immune serum globulins (Gammaglobulins) are generated from what ?

Platelet Poor Plasma

7

Whole blood centrifuged via 4 degees celcius produces what ?

Platelet Rich Plasma
Packed Red Cells

8

Platelet Rich Plasma centrifuged via 20 degrees celcius produces what ?

Platelet Poor Plasma
Platelets

9

Platelet Poor Plasma frozen down to -70 degrees celcius produces what ?

Factor VIII deficient plasma

10

Packed Red Cells Frozen down to -80 degrees celcius produces what ?

Frozen red cells

11

Packed Red Cells produces what ?

Leukocyte poor Red Cells

12

Platelet Poor Plasma frozen down to -20 degrees celcius provides what ?

Fresh Frozen Plasma with a therapeutic concentration of ATIII.
Can be stored up to 1 year at -18 degrees celcius

13

Platelet Poor Plasma frozen down to -70 degrees celcius and then THAWED out produces what ?

Cryoprecipitate

14

Systems in place to prevent inappropriate activation of TPA ?

Aplha 2 - Plasmin Inhibitor
Alpha 2 - Macroglobulin
C1 Inactivator

15

What is the role of Alpha 2 - Antiplasmin ?

Inactivates any plasmin outside of the clot.

16

Gray platelet syndrome

Platelets cannot adhere to the endothelium

17

Sequestration

1/3 of platelets are sequestered by the spleen

18

How does Thromboxane A2 regulate ADP ?

Increases release of ADP synthesized by the platelet membrane.

19

How does PGI2 regulate ADP ?

Decreases the release of ADP synthesized by the endothelial cells lining the blood vessel.

20

Transitory Thrombocytosis ?
450k - 600k

Exercise and stress releases sequestered platelets by the lungs and the spleen.

21

Reactive Thrombocytosis ?
600k - 800k

Caused by increase production in the bone marrow as a result of inflammatory diseases, ect.

22

Primary Thrombocytosis ?
1million

Caused by myeloproliferative disorder of stems cells.

23

Treatment for vWF disease?

Desmopressin Acetate = releases stored vWF
Replacement Factor VIII
vWF Concentrates
FFP
Cryoprecipitate

24

Coumadin works by?

Inhibits vitamin K dependent factors (II, VII, IX, X, protein C, and protein S). Effect seen 3 - 5 days.

25

Name 2 Xa Inhibitors ?

XARELTO
ELIQUIS ( apixaban)

26

Name 5 Direct thrombin Inhibitors ?

PLHAB

1.) Hirudin, R-hirudin
2.) Lepirudin
3.) Bivalirudin
4.) Argatroban (Acova)
5.) Pradaxa

27

Anticoagulants for patients with HIT ?

- delay surgery
- use heparin with protamine reversal during surgery

Hirudin, Lepirudin, or Argatroban.
But the most common used is Bivalirudin.

28

What else can we give to conteract heparin besides Protamine ?

Polybrene 1 u / mL

29

How do you calculate INR ?

(Patients PT / Mean Normal Prothrombin Time ) ^ International sensitive Index 1.297

30

What is a normal INR ?

0.8 - 1.3

31

With what INR value can we expect clotting ?

< 0.5

32

With what INR value can we expect bleeding ?

3.0 - 5.0

33

What is the recommended therapeutic range for PE, DVT, Prophylaxis, & A-Fib ?

2.0 - 3.0

34

What is the recommended therapeutic range for prosthetic heart valves and recurrent systemic embolism?

3.0 - 4.5

35

Plavix bind to what receptor on the platelet ?

P2Y12

36

Fibrinogen binds to what receptor on the platelet?

GPIIb / IIIa (Alpha 2BBIII)

37

Collagen binds to what receptor on the platelet ?

GP1A / 2A (Aplha 2B1)

38

vWF binds to what receptor on the platelet ?

GP1b - IX - V

39

Hemophelia is carried by females but expressed by ?

Males

40

Gangrene AKA ?

Hemophilus B Septicemia

41

Hemorrhagic Purpura is due to what?

Miningococcal Septicimia