Flashcards in Bone Path II Deck (21):
What are the Clinical Features of Hyperparathyroidism?
Bones, Stones, Groans(GI), Moans(CNS)
What is the effect of PTH?
Inc Resorption of Ca by renal Tubules
Inc synth of active VD by kidneys => Inc Ca abs from gut
What is the Phys Effect of Hyper PTH?
Inc SERUM Ca and Phosphate
WHat are the bone changes occurring from HPTH?
Causes Bone Cysts and Brown Tumors
WHat are the effects of Renal filure in Renal osteodystrophy?
Renal Failure => D3 Deficiency => HypoCa => 2^HPTH
WHat are the effects ofHPTH in Renal osteodystrophy?
Inc PTH => Inc Osteoclasts => Inc Serum Ca and Phos => Bone cysts and Brown tumors
What are the traits of Paget's disease of bone?
1) Osteoclast mediated bone resorption
2) Imperfect osteoblast-med bone repair Early(1) Late (2)
What type of virus is thought to contribute to Paget's disease of bone?
What is the Mnemonic for Different Collagen types?
FOUR is floor (Basement Membrane)
What is Avascular Necrosis?
Infarct of bone and marrow
What are the causes of Avascualr necrosis?
Fracture, Corticosteroids, Idiopathic****
Thrombus and Embolism, vasculitis, radiation, inc intraosseus pressure
What are the steps of Fracture Healing?
Bleeding =>Organization of Hematoma (procallus) => fibrocartillaginus callus => Mesenchymal cells replaced by osseus callus
What are the inhibitors of Fracture healing?
Infection, Non-union, Inadequate immobilization, poor circulation/nutrition, drugs(imm-supp), systemic abnormality
What are the routes of Osteomyelitis?
Hematogenous, Extension from adjacent acute inflammation, from open fracture or surgery
What is the most common microbe causing osteomyelitis?
Staph Aureus. Salmonella in sickle cell patients (asplenic?)
What are the traits of Chroic Osteomyelitis?
infection surrounded by rim of reactive bone. Involucrum
What are the outcomes/ complications of Chronic Osteomyelitis?
Heal, Drain into sinus tract, walled off => Brodie abcess
Pathologic fracture, endocarditis, sepsis, Sq Cell CA
Well defined rim of sclerotic bone surrounds residual abcess
What are the traits of Tuberculous Osteomyelitis?
Hematogenous spread, long bones and VERTABRAE. Pott Disease