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Flashcards in Bone Path II Deck (21):
1

What are the Clinical Features of Hyperparathyroidism?

Bones, Stones, Groans(GI), Moans(CNS)

2

What is the effect of PTH?

Inc Resorption of Ca by renal Tubules
Inc synth of active VD by kidneys => Inc Ca abs from gut

3

What is the Phys Effect of Hyper PTH?

Inc SERUM Ca and Phosphate

4

WHat are the bone changes occurring from HPTH?

Causes Bone Cysts and Brown Tumors

5

WHat are the effects of Renal filure in Renal osteodystrophy?

Renal Failure => D3 Deficiency => HypoCa => 2^HPTH

6

WHat are the effects ofHPTH in Renal osteodystrophy?

Inc PTH => Inc Osteoclasts => Inc Serum Ca and Phos => Bone cysts and Brown tumors

7

What are the traits of Paget's disease of bone?

Simultaneous:
1) Osteoclast mediated bone resorption
2) Imperfect osteoblast-med bone repair Early(1) Late (2)

8

What type of virus is thought to contribute to Paget's disease of bone?

Paramyxovirus

9

What is the Mnemonic for Different Collagen types?

bONE
carTWOlage
reTHREEculate(reticulate)
FOUR is floor (Basement Membrane)

10

What is Avascular Necrosis?

Infarct of bone and marrow

11

What are the causes of Avascualr necrosis?

Fracture, Corticosteroids, Idiopathic****
Thrombus and Embolism, vasculitis, radiation, inc intraosseus pressure

12

What are the steps of Fracture Healing?

Bleeding =>Organization of Hematoma (procallus) => fibrocartillaginus callus => Mesenchymal cells replaced by osseus callus

13

What are the inhibitors of Fracture healing?

Infection, Non-union, Inadequate immobilization, poor circulation/nutrition, drugs(imm-supp), systemic abnormality

14

What are the routes of Osteomyelitis?

Hematogenous, Extension from adjacent acute inflammation, from open fracture or surgery

15

What is the most common microbe causing osteomyelitis?

Staph Aureus. Salmonella in sickle cell patients (asplenic?)

16

What are the traits of Chroic Osteomyelitis?

"Sequestrum"

17

"Sequestrum"

infection surrounded by rim of reactive bone. Involucrum

18

What are the outcomes/ complications of Chronic Osteomyelitis?

Heal, Drain into sinus tract, walled off => Brodie abcess
Pathologic fracture, endocarditis, sepsis, Sq Cell CA

19

Brodie abcess

Well defined rim of sclerotic bone surrounds residual abcess

20

What are the traits of Tuberculous Osteomyelitis?

Hematogenous spread, long bones and VERTABRAE. Pott Disease

21

What are the Effects of Pott Disease?

Vertebral deformity and Collapse => Neurologic Deficits