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Flashcards in Metabolic Bone Disease Deck (33):
1

What is Osteoporosis?

Bone Deterioration w/ Reduced bone mass.
Disruption of micro architecture of bone
Inc risk of fracture

2

What is Osteoporosis?

Bone Deterioration w/ Reduced bone mass.
Disruption of micro architecture of bone
Inc risk of fracture

3

What does the T-Score of Bone density tell you?

Comparison to young Adults

4

What does the Z-Score of Bone density tell you?

Comparison to Age matched adults

5

What T score is equated to osteoporosis?

T score

6

What T score is equated to Low bone density (osteopenia)?

-1.0 to -2.5

7

What is a normal T score?

-1.0 to +1.0

8

Who should T-Score NOT be used for?

Children
Pre-Menopausal Women
Men

9

When is a Z score used?

Pt younger than peak bone mass
Pre-Menopausal Women
BD Lower than expected
Men

10

What are clinical Risk factors for fragility fracture?

Advancing age
Prev Fracture
GLC Thx
Parental Hx of Hip Fracture
Low Body Wt
Smoking, EtOH, RA, 2^ OP

11

What are clinical Risk factors for fragility fracture?

Advancing age
Prev Fracture
GLC Thx
Parental Hx of Hip Fracture
Low Body Wt
Smoking, EtOH, RA, 2^ OP

12

What is the Reccomended Daily Ca intake?

800 to 1000 IU/d of Vit D3

13

What does the Z-Score of Bone density tell you?

Comparison to Age matched adults

14

What T score is equated to osteoporosis?

T score

15

What T score is equated to Low bone density (osteopenia)?

-1.0 to -2.5

16

What is the MOA of DENOSUMAB?

Binds RANK ligand and Inh Osteoclast Med-Bone Destruction

17

Who should T-Score NOT be used for?

Children
Pre-Menopausal Women
Men

18

When is a Z score used?

Pt younger than peak bone mass
Pre-Menopausal Women
BD Lower than expected
Men

19

What Z-Score equates to 2^ osteoporosis?

less than -2.0

20

What are clinical Risk factors for fragility fracture?

Advancing age
Prev Fracture
GLC Thx
Parental Hx of Hip Fracture
Low Body Wt
Smoking, EtOH, RA, 2^ OP

21

What kind of rickets is caused by Dietary Def of Vit D and/or Ca?

Calcipenic Rickets

22

What is the Reccomended Daily Ca intake?

800 to 1000 IU/d of Vit D3

23

What testing is recommended for women >65 and Men >70?

BMD testing

24

What are the limitations of FRAX?

only applied to Pts naive to Tx
Only T-Score from the hip. not peripheral or Spine T-Score

25

What is the Tx of Osteoporosis?

Anticat Bisphosphonates/ SERM/Denosumab) vs Anabolic Thx

26

What is the MOA of DENOSUMAB?

Binds RANK ligand and Inh Osteoclast Med-Bone Destruction

27

What are the traits of Paget's Disease of the bone?

Abn of the osteoclast. accel bone turnover and abn bone remodeling. AD w/ var penitrance

28

What are clinical signs of PDB?

Radic due to Nerve Compression, Back pain, Hearing loss, headache, Joint rep surgery, High OP HF. Hyper Calcuria

29

What are lab findings in PDB?

Inc bone turnover => Inc Alk phos, Bone TO markers increased => Ca and Phos normal

30

What is the Treatment of PDB?

Monitor Alk phos
Bisphosphonates - Zoledronic Acid

31

What kind of rickets is caused by Dietary Def of Vit D and/or Ca?

Calcipenic Rickets

32

What kind of rickets is caused by Renal Phosphate Wasting?

Phosphopenic Rickets

33

What are the lab findings in Osteomalacia?

Alk phos Elevated
Serum Ca and Phos reduced
Urine Ca low in 87%
Low 25 OH VD
PTH elevated