Flashcards in Osteoarthritis Deck (15):
What are the three Radiographic Changes seen in Osteoarthritis?
Joint Space Narrowing
What is the Pathology Associated with Osteoarthritis?
Articular cartilage Loss
Osteophyte and Bony Sclerosis Devt
Inflam Infiltrates in synovium
What distripution of joint involvement in OA?
What is the Non-Pharma Tx of OA?
Pt Education, ADLs, PT and OT, Thermal Modalities, Weight loss, Exercise, Assistive Devices, Joint Protection, Splints
What are the Pharma-Tx for OA?
Tramadol, NSAIDS, APAP, Hyaluronates, Topical Capcasin
What are the risks of NSAIDS?
Stomach ulcers/GI effects
What are the risks of COX-2 Spec NSAIDS?
Potential Risk of CV events
What is the overall Managment goal of OA?
Improve Quality of life
Pharm and non-pharm Tx
Avoid Theraputic Tox
What are the Dx Criteria of RA?
Arthritis in >3 joint areas
Arth of Hand joints
Serum Rheum Factor
What is seen on labs in RA?
Acute Phase Response
What is the Tx of RA?
Corticosteroids: Systemic or Intra-articular, "Bridge Thx"
NSAIDS: Pain/Stiff but not disease mod
What are the Ocular Effects of RA?
Eye Dryness => Scleritis
What are the Traits of Methotrexate Therapy in RA?
Safe, Tolerable and Effective
SE: Hepatic Fibrosis, BM tox, Pulm Tox. OK as monothx
What are the Traits of DMARD thx in RA?
Not everyone Responds, Slows progress, but doesn't prevent, SE, Part of Combo Thx