Osteoarthritis Flashcards Preview

Rheum Ortho > Osteoarthritis > Flashcards

Flashcards in Osteoarthritis Deck (15):
1

What are the three Radiographic Changes seen in Osteoarthritis?

Joint Space Narrowing
Subchondral Sclerosis
Osteophite Formation

2

What is the Pathology Associated with Osteoarthritis?

Articular cartilage Loss
Osteophyte and Bony Sclerosis Devt
Inflam Infiltrates in synovium
Lax Ligaments
Weak muscles

3

What distripution of joint involvement in OA?

Symetric Polyarthritis

4

What is the Non-Pharma Tx of OA?

Pt Education, ADLs, PT and OT, Thermal Modalities, Weight loss, Exercise, Assistive Devices, Joint Protection, Splints

5

What are the Pharma-Tx for OA?

Tramadol, NSAIDS, APAP, Hyaluronates, Topical Capcasin

6

What are the risks of NSAIDS?

Stomach ulcers/GI effects

7

What are the risks of COX-2 Spec NSAIDS?

Potential Risk of CV events

8

What is the overall Managment goal of OA?

Control Pain
Improve Quality of life
Pharm and non-pharm Tx
Avoid Theraputic Tox

9

What are the Dx Criteria of RA?

Morning Stiffness
Arthritis in >3 joint areas
Arth of Hand joints
Symmetric Arthritis
Rheum Nodules
Serum Rheum Factor
Radiographic Changes

10

What is seen on labs in RA?

Rheumatoid Factor
Anti CCP
Acute Phase Response
ANA

11

What is the Tx of RA?

Corticosteroids: Systemic or Intra-articular, "Bridge Thx"
Multiple SE
NSAIDS: Pain/Stiff but not disease mod
DMARDS
Methotrexate

12

What are the Ocular Effects of RA?

Eye Dryness => Scleritis

13

What are the Traits of Methotrexate Therapy in RA?

Safe, Tolerable and Effective
SE: Hepatic Fibrosis, BM tox, Pulm Tox. OK as monothx

14

What are the Traits of DMARD thx in RA?

Not everyone Responds, Slows progress, but doesn't prevent, SE, Part of Combo Thx

15

What are the traits of Anti TNF Therapies for RA?

Most potent Available. Combo w/ Methotrexate, Inc Granulomatous infections (TB Histoplasma), Malignancy, $$$