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Flashcards in Bone Pathology Deck (22):
1

What is Uncalcified bone called?

Osteoid

2

What receptors are found on Osteoblasts?

RANK-L

3

What are osteoclasts derived from?

Hematopoetic Progenitor Cells

4

What pervents parts of bone from being resorbed?

Lined w/ osteoid

5

What is the difference between Woven and Lamellar bone?

Woven: Random weave
Lamellar: Organized. Stronger

6

Where is Woven bone seen?

Fetal skeleton and growth plates, Callus, Fibrous Dysplasia, Surrounding tumor or infection

7

What are the traits of Achondroplasia?

Dwarfism. Def in signal transduction. FGFR Persistently activated. Dec prolif of chondrocytes @ growth plates. AD. HH Lethal
Hh Dwarfed

8

What are the zones of The Growth Plate?

1) Reserve Z
2) Proliferation Z
3) Hypertrophy
4) Mineralization
5)Primary Spongiosa

9

What are the Clinical findings of achondroplasia?

Shortened proximal extremities
Sway Backed posture
Enlarged head w/ fontanel

10

What is the defect in Osteogenesis Imperfecta?

Type 1 collagen synthesis
AD. Brittle Bones

11

What are the 4 major types of OI?

1) inc risk of fracture but not deforming
2) Lethal: In utero demise
3/4) Survive fracures in infancy/childhood but have progressive Deformity

12

What are the features of OI type 1?

Blue Sclerae, Dental and hearing problems, Inc risk lof fracture

13

What are the traits of Osteopetrosis?

Marble bone disease
Dec in Osteoclastic bone resorption => skeletal sclerosis. Inc mineralization
Thick brittle bones

14

What are the hematologic signs of Osteopetrosis?

Anemia, thrombocytopenia, Inc risk of infection

15

What are the traits of Osteoporosis?

Reduced bone mass
Cortex and Trabeculae are thinned

16

How do Osteoblast and clasts interact?

RANK ligand on surface of OClast precursor stim by OBlast => diff to mature OClast

17

What is the Effect of Dec Estrogen on Osteoclasts?

Inc IL-1, IL-6, TNF => Inc RANK => Inc Osteoclasts => Bone resporption => Dec Osteoprotegrin

18

What are the 2 types of Vertebral Fractures?

Wedge Fracture => Kyphosis
Burst Fracture => SC disruption

19

What are the effects of Glucocorticoids on the Bones?

Dec Osteoclastogenesis
Dec Osteoblastogenesis =>
Osteonecrosis and Fracture

20

What are the traits of Rickets and osteomalacia?

VD Deficiency => Defective Matrix Mineralization
Softening of Bone => Frac/ deformity

21

What are the Clinical signs of Osteomalacia?

...

22

What are the Clinical signs of Rickets?

Imp growth, Pigeon Chest, notched ribs, Dental Defects, Rachitic Rosary, Enl abdomen, chronic cough,(Ribs don't grow)