Bone Path III Flashcards Preview

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Flashcards in Bone Path III Deck (25):
1

What are the 5 questions to ask with Bone neoplasia?

1) Pattern of Growth
2) Producing anything
3)Look like?
4) Cell/imaging => Ben/Mal
5)Dx agree w/ clinical picture and radiologic appearance?

2

Where does Ewing Sarcoma usually occur?

Diaphysis (shaft)

3

Where does Giant Cell Tumor usually occur?

Epiphisis (End of bone)

4

Where does Chondrosarcoma usually occur?

Metaphysis (center)

5

Where does Osteosarcoma usually occur?

Physis (off Center)

6

What are the traits of an osteoma?

Benign tumor of mature bone
Asymptomatic
Local and mechanical problems
Cortical Bones of Skull and Face

7

What are the Traits of osteoid osteoma and Osteoblastoma?

Benign. X-Ray Central Area of tumor radiolucent.
PAINFUL lesions relieved by aspirin (OO, not in OBA)

8

What are the traits of Osteoblatoma?

Vertebral column
Radiolucent nidus
Histo Identical to OO
Pain not relieved by Aspirin

9

What are the Traits of Osteosarcoma?

MALIGNANT
Have to See OSTEOID
Most common 1^malignant tumor of bone
BIMODAL Age Distribution
Metaphysis of long bones

10

What are the clinical traits of Osteosarcoma?

Bone PAIN, Swelling, Path Fracture
AGRESSIVE 20% w/ pulm mets at time of Dx

11

What are the most common locations for Osteosarcoma?

Around Knee 60%
Prox Femur 15%
Prox Humerus 10%

12

What is Codman's Triangle?

Elevation of periosteum to produce an angle between surface of involed bone

13

Lamellated

Multilayered "Onion Skin"

14

Spiculated

"Sunburst" or "Hair on End"

15

What are the traits of Osteochondroma?

Young men
Metaphysis, Epiphyseal Plate, Polypoid Growth on x ray. Tx: Excision

16

What are the Traits of Chondroma?

Benign tumor of Hyaline Cartilage. Well circumscribed. Medullary cavity => Enchondromas

17

What is Ollier Disease?

Multiple Enchondromas

18

What is a chondrosarcoma?

Pelvic Bones, Axial Skeleton, Multilobular. Prog depends on Grade and size

19

What factors tell you agressiveness of Chondrosarcoma?

Cellularity, Deg of nuclear atypia, Mitotic activity

20

What are the traits of Ewing Sarcoma?

Small round blue tumors. Primitive Neural tumor
EWS => Undiff
PNET => Neural Diff

21

What are found on Histology of Ewing Sarcoma?

Uniform "Small round blue" cells w/ round nuclei "nested" aggregates
PAS
CD99 +

22

What are the traits of Fibrous Cortical Defect?

Common. Devt Defect. Metphysis. Multiple commonly in the knee. Small. Asymptomatic. incidental X-ray finding.

23

What are the traits of Fibrous Dysplaia?

Woven Bone. Good Prognosis. Radiolucent, in diaphysis

24

What are the traits of Giant cell tumors of Bone?

Osteoclastoma. Unommon. EPIPHYSIS of long bones around the knee. Mature skeleton.

25

What are the traits of Metastatic tumors to bone?

Most OSTEOLYTIC
some osteoblastic (prostate)
Usually multiple