Flashcards in Bone Pathology II: Bone Neoplasms Deck (25):
Are primary bone neoplasms rare?
Benign tumor like mass of abnormally dense bone
Where are osteomas commonly found?
What age do osteomas typically appear?
4th to 5th decade
- Epidermal cysts
- Colonic adenomatous polyposis
Benign highly vascular and well-circumscribed osteoblastic proliferation that is almost always singular
Where are osteoid osteomas typically found?
What is the characteristic appearance of osteoid osteoma on x-ray?
High grade sarcoma most often seen younger patients and presents as a painful tender mass
What is the most common location of osteosarcoma?
Triangular shadow between the cortex and raised ends of periosteum as the tumor has broken through the cortex and lifted the periosteum
Outgrowth of medullary and cortical bone covered with a cartilaginous cap that is more of a malformation than a neoplasm
Multiple hereditary osteochondromas
Malignant cartilage forming tumor
What gender is more affected by chrondrosarcoma?
Primary osseous neoplasm of small and round mesenchymal cells which are rich in cytoplasmic glycogen
What is the chromosome tranlocation seen in Ewing's sarcoma?
What is the result of the t(11;22) translocation in Ewing's sarcoma?
EWS/FLI-1 gene fusion which over expresses MIC2
Benign intramedullary proliferaton of fibrous and bone tissue
What is the radiographic appearance of fibrous dysplasia?
- Polyostotic fibrous dysplasia
- Precocious pubert
- Unilateral macular pigmented skin lesions
- Fibromyxomatous soft tissue tumor
- Recurrent fractures
What mutation is McCune-Albright's Syndrome associated with?
Giant Cell Tumor of Bone
Locally aggressive bone neoplasm with large number of osteoclast-like giant cells with mononuclear cells in background
What are common metastases to the bone?