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► Med - Pathology > HIV > Flashcards

Flashcards in HIV Deck (24):
1

Are retroviruses enveloped?

Yes

2

What is the function of GP120?

GP120 binds receptors, CD4 and chemokine coreceptors CCR5/CXCR4.

3

What is the function of GP41?

GP120 is noncovalently connected to gp41, the transmembrane rods here. GP41 is needed for the virus to enter cells.

4

What receptor if not express confers immunity to HIV?

CCR5

5

Where does HIV replicate?

Nucleus

6

What is the function of protease inhibitors in anti-retroviral therapy?

Capsid maturation of HIV

7

Is HIV highly contagious?

No, HIV is not particularly infectious or contagious

8

Is HIV destroyed by soap?

Yes

9

Where is HIV most prominent in the world?

Africa

10

What immune cells does HIV target?

CD4+ T cells

11

What is the normal CD4+ T cell level?

1000 cells per cubic mm

12

What is the course of HIV infection?

- Acute
- Latent
- AIDS

13

What is the acute HIV infection?

- Mononucleosis‐like syndrome
- Fever, fatigue, swollen lymph nodes
- T cell levels will drop but can rebound slightly

14

What is clinical HIV latency?

- Typically lasts 8-12 years following primary infection
- Few manifestations

15

HAART

Highly Active Anti-Retroviral Therapy

16

What is the goal of HAART?

Lower viremia which slows disease progression

17

What are the 2 targets of HAART?

- The RT inhibitors block reverse transcription
- The protease inhibitors prevent virion capsid morphogenesis

18

How is HTLV transmitted?

Sexually

19

What does HTLV cause?

HTLV causes T cell leukemias - encodes Tax which induces cell proliferation

20

A 30‐year old man infected with HIV begins to have difficulty with activities of daily living. He has memory problems and decreased ability to perform functions that require fine motor control, such as writing and painting. His CD4+ lymphocyte count is 150 cells per microliter. Which of the following cell types is most important for disseminating HIV into the central nervous system?

A. Natural killer cell
B. Macrophage
C. Neutrophil
D. CD8+ lymphocyte
E. Langerhans cell

B. Macrophage

21

Where does reverse transcription of HIV occur?

Cytoplasm

22

What does env encode?

Encodes gp120/41

23

What does gag encode?

Encodes group antigens

24

What does pol encode?

Encodes the enzymes in the virion, reverse transcriptase, RNaseH, integrase, protease.

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