Flashcards in Crystal Arthropathies Deck (29):
What is the salt found in gout?
Monosodium urate monohydrate
What gender is more affected by gout?
What are some risk factors for gout?
- Metabolic Syndrome
- Thiazide Diuretics
- Supersaturation of uric acid
- Crystal formation which activate immune system
- Trigger complement cascade which
- Phagocytosis by monocytes activates intracellular inflammasome
What is the most likely cause of gout, overproduction or under excretion?
What are the 2 important enzymes on the urate synthesis pathway?
- Xanthine Oxidase
Typical pain of gout found in the big toe - acute involvement of 1st MTP
Calcium Pyrophosphate Deposition Disease is AKA....
What are the joints most often involved in pseudo gout?
Knees and wrist
What population is pseudo gout seen in?
Calcium crystal deposition in meniscus of the knee and triangular cartilage of the wrist
- Hydroxypatite associated destructive arthritis
- Elderly females with destruction of rotator cuff and glenohumeral joint
Autoimmue disorder that causes pain and stiffness in proximal joints and muscles
- Shoulders and hips, neck muscles can be affected
What disease is polymyalgia rheumatica associated with?
Giant Cell Arteritis
What gender is more affected by polymyalgia rheumatica?
Chronic widespread pain with 11 or more tender points - more likely in women
Tenosynovial Giant Cell Tumor
Most common benign neoplasm of the synovium and is associated with translocation fusing the promoter of the collagen 6A3 gene to the coding sequence of M-CSF - can be localized or diffuse
Multiple nodules of hyalgine cartilage within subsynovial connective tissue with the knee most commonly affected - benign
What are foods to avoid for gout patients?
- Red meat
Xanthine oxidase inhibitor - decreases the uric acid generated
What is poodagra indicative of?
What is positive birefringence indicative of?
CPPD - pseudogout
What is negative birefringence indicative of?
What biologic anti-inflammatory can be used in pseudo gout?
Where can hydroxyapatite also be found?
In the tendons
What is the treatment for polymyalgia rheumatica?
What is a major trigger/cause of fibromyalgia?
Lack of sleep - decreases pain tolerance
What is the joint most likely affected by Tenosynovial Giant Cell Tumor?