Clinical Dermatology Flashcards Preview

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Flashcards in Clinical Dermatology Deck (34):
1

What is the difference between dermatomyositis and cutaneous lupus?

Cutaneous histology almost identical to acute lupus except frequently more epidermal atrophy

2

What are the clinical findings with dermatomyositis?

- Violaceous papules on the knuckles (Gottron's Papules)
- Heliotrope rash on the upper eyelid
- Shawl sign over the upper back that is VERY itchy

3

What are the clinical findings of cutaneous lupus - acute lupus erythematosis?

- Butterfly rash that spares the nasolabial folds
- Photosensitivity

4

What is cutaneous lupus highly associated with?

Systemic Lupus Erythematous

5

What are the clinical features of Discoid Lupus Erythematosus?

- Scarring depressed plaques
- Lichenoid dermatitis with vacuolar interface change

6

Do most patients with DLE have SLE?

No

7

What areas of the hand are spared in lupus?

Knuckles

8

What are the clinical features of scleroderma?

• “Bound‐down” skin
• Sclerodactyly
• Decreasedoral aperture
• May affect other organ systems
• 75% Female

9

What is CREST syndrome?

More mild scleroderma
– Calcinosis cutis
– Raynaud’s
– Esophageal dysmotility
– Sclerodactyly
– Telangiectasias

10

What is the Ab found in CREST?

Anti-centromere Ab

11

Who does Raynaud's generally affect?

Women

12

Raynaud's Disease

Vasospasm of small vessels with pain and color change

13

White atrophic plaques that are often associated with localized scleroderma - can be seen in the genital area

Lichen Scelrosus

14

- Non-caseating granulomas
- Often seen in scars or sites of trauma
- Elevated ACE levels

Sarcoidosis

15

What is necrobiosis lipoidica associated with?

Diabetes

16

Pyoderma Gangrenosum

Autoimmune disease that leads to ulceration

17

What is pyoderma gangrenous associated with?

- Inflammatory arthritis
- Inflammatory bowel disease

18

What is calciphylaxis associated with?

End stage renal disease

19

- Type III Hypersensitivity Reaction
- Small purpuric papules
- Predominantly lower legs

Leukocytoclastic Vasculitis

20

Where are arteriovenous malformations most commonly found?

On the face

21

Viral Exanthem

Erythematous blanching macule and papillose that coalesce - most common in the summer and fall

22

- Vesicles on the pals and soles of the feet as well as oral lesion
- Fever prodrome
- Benign course

Hand, Foot and Mouth Disease - Coxsackie Virus

23

- Slapped cheecks
- Reticulated eruption on extremities
- Arthralgia

Parovirus B19 Infection

24

What can fetal infection by parvovirus B19 cause?

Anemia, fetal hydrops or death

25

- Pruritic edematous non-scaly plaques - wheals
- Swelling from plasma leakage
- Type 1 Hypersensitivity

Urticaria

26

Urticaria Pigmentosa

- Red-brown papules
- Mast Cells are present
- NOT the same as urticaria

27

- Numerous pink papillose coalescing over torso and proximal extremities due to a "bug or drug" reaction
- Found in folds of skin mostly

Exanthematous Drug Eruption

28

DRESS Syndrome

- Facial swelling and LAD
- Delayed onset
- Visceral involvement

29

What are the causes of erythema multiforme?

Drug reactions
- Anti-convulsants
- Antibiotics
- Sulfonamides
- Allopurinol

30

What are the causes of Stevens Johnson Syndrome?

Infections - HSV and Mycoplasma

31

What does SPF measure?

ONLY UVB protection

32

Lichenoid dermatitis with superficial and deep perifollicular dense lymphocytic inflammation often with dermal mucin and thickening of the basement membrane.
- Scarring alopecia

DLE

33

Spares lichenoid dermatitis with basal vacuolar change.
- Butterfly rash
- Spares nasolabial folds

Acute Lupus

34

- Shawl sign
- Gottron’s papules on knuckles
- Holster sign on hips
- Cuticular hypertrophy
- Violaceous “heliotrope” color
- Associated with proximal muscle weakness

Dermatomyositis

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