Flashcards in Bordetella pertussis, Haemophilus influenzae, Legionella pneumophila Deck (77)
Describe the structure of Bordetella pertussis.
Small, G- Coccobacillus
Bordetella pertussis is associated with _______ in virulent strains.
Incubation time of Bordetella pertussis?
Three stages of Bordetella pertussis?
Describe symptoms in the catarrhal stage of Bordetella pertussis infection.
Low grade fever, runny nose, worsening cough
Describe the clinical presentation of the paroxysmal stage of Bordetella pertussis infection.
Severe Cough -- So prolonged/irritated that inhalazion is wheezy and vomiting occurs
Lymphotoxicity results in leukocyte prolif
Common name of Bordetella pertussis?
Describe the Bordetella pertussis convalescent stage.
Cough becomes less severe for about 45 days
"The Cough of 100 days"
Complications of Bordetella pertussis?
How is Bordetella pertussis spread?
Why is Bordetella pertussis so prone to spread?
It is highly contagious
It is rarely detected before spread
In what stage is Bordetella pertussis most contagious?
Who is most prone to get Bordetella pertussis? Who is it most dangerous in?
Most dangerous in small airway
Four causes of Bordetella pertussis?
Increased Toxin Production
Vaccine targets few antigens
Low coverage of booster vaccine
Six virulence factors of Bordetella pertussis
Calmodulin-dependent adenyl cyclase
What is the activity of filamentous hemagglutinin?
- Allows Bordetella pertussis to bind specifically to glycoprotein receptor on ciliated epithelial cells
- Aided by pertactin surface protein, pili, pertussis toxin
What is the clinical significance of filamentous hemagglutinin?
Ciliary stasis of mucociliary escalator
(can't sweep bacteria out of resp. tract)
Describe the six parts of pertussis toxin.
5 B parts bind to ganglioside for ciliated cells
A part - ADP ribosylates an inhibitory G ptorein
What does ribosylating the inhibitory G protein in Bordetella pertussis cause problems
Prevents inactivation of adenyl cyclase (inc. cAMP)
Increases H2O secretion in respiratory tract
Difference between pertussis toxin and cholera toxin.
Pertussis locks in stimulated/active form
Cholera blocks the inhibitory form
Effect of calmodulin-dependent adenyl cyclase.
Additional ACase, only active in eukaryotic cells
Role of dermonecrotic toxin? Who secretes it?
Secreted by T3SS
What is tracheal cytotoxin? What does it do?
Soluble peptidoglycan residue
Kills ciliated epithelial cells
What two lipids are contained in LPS?
Lipid A and Lipid X (half of A)
How is Bordetella pertussis controlled?
DTap Vaccine 3 times before 1st birthday, boosters
How can Bordetella pertussis be treated? What stage must a patient be in?
Describe Bordetella parapertussis
Similar to whooping cough, less severe
Have cryptic ptx operon
Describe the physical structure ofHaemophilus influenzae
Some have capsule
Difference between typable and non-typable Haemophilus influenzae?
Typable have capsule, non-typable do not