(Mostly) Sexually Transmitted Diseases Flashcards Preview

Micro Exam #2 > (Mostly) Sexually Transmitted Diseases > Flashcards

Flashcards in (Mostly) Sexually Transmitted Diseases Deck (121)
Loading flashcards...
1

Treponema pallidum is commonly referred to as...

Syphilis

2

Describe the structure of Treponema pallidum

Long, thin spirochete
- Unseen in light microscope, seen by silver stain

3

What type of microscope can view Treponema pallidum?

Dark Field Microscope

4

What surrounds every Treponema pallidum cell?

Glycosaminoglycan sheath

5

How is Treponema pallidum made motile?

Endoflagella within the periplasm (3 per end)

6

What is unique about Treponema pallidum's envelope?

No LPS
Cardiolipin in membrane

7

Does Treponema pallidum have many outer membrane proteins? Significance of this knowledge?

Few OM proteins
Makes it hard for immune system to find it and make Abs

8

Method used to culture Treponema pallidum?

None. So far unculturable in lab
Grown in rabbit testes instead

9

Oxygen metabolism of Treponema pallidum?

Microaerophilic

10

What is a chancre?

Defined, Unpainful papule at site of infection

11

Describe the symptoms common to Primary Treponema pallidum infection.

Ulcerated, Chancre, Regional LN swelling
Heals spontaneously, but organisms remain in blood

12

Describe the clinical presentation of secondary Treponema pallidum infection.

Red macular/macropapular rash anywhere
Condylomas in mount areas

13

What is unique about the red macular/macropapular rash of Treponema pallidum?

One of few to appear on soles and palms

14

What is a condyloma?

Raised, White, wart-like papule (seen in Treponema pallidum)

15

Difference between the early and late latent period?

Early -- Within a year of secondary
Late -- 1-20+ years

16

What is tertiary Treponema pallidum response?

Lesions of tissues through body caused by immune response

17

Why can't you culture a tertiary Treponema pallidum response?

Treponema pallidum hasn't been able to be cultured so far
Even if it could, its only immune response at this point, not the actual bacteria

18

Important causes of vertically transmitted disease

Toxoplasma
Other -- HIV, Coxsackie, Chicken Pox, etc.
Rubella
Cytamegalovieus
HErpes
Syphilis

19

Clinical presentation of tertiary Treponema pallidum response?

Gummas
Bones: porous, bendable, fragile
Heart: aorta swells, ruptures
liver
CNS

20

Two manifectstions of Treponema pallidum in the CNS

Brain -- General paresis
Spine -- tabes dorsalis

21

Significance of Treponema pallidum in pregnant women?

20% abortion or stillbirth
80% have congenital defects

22

Primary defects associated with Treponema pallidum transmission in utero? (Name the group name)

Hutchison's triad

23

What does Hutchison's Triad entail?

Blindness
VIII Nerve Deafness
Hutchison's Teeth

24

What are Hutchison's Teeth?

Double pointed incisors

25

What organisms can carry Treponema pallidum?

Only humans

26

How is Treponema pallidum transmitted?

Exclusively STD

27

How long are infected individuals contagious with Treponema pallidum?

3-5 years

28

What population is seeing the most rapid increases in Treponema pallidum diagnosis?

Over 50

29

Two groups that should always be tested for Treponema pallidum

High-Risk Populations
After any stillbirth

30

Describe the infectivity and molecular mechanism of Treponema pallidum infection.

Highly infectious
Hyaluronidase facilitates spread/invasion of tissues + Rapid Motility