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Flashcards in Gastrointestinal Organisms Deck (87)
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1

Physical characteristics of enterobacteriaceae?

Facultatively anaerobic
G- Rods

2

Enterobacteriaceae use what type of secretion system?

3

3

What antigens are used to type Enterobacteriaceae.

O, H, K/Vi

4

Biochemical tests for Enterobacteriaceae?

IMViC
Carbohydrate fermentation
Packaged Test Kits

5

What does IMViC stand for?

Indole methyl red Voges-Poskauer citrate

6

How are carbohydrate fermentations occur?

Use MacConkey's Agar (Lactose)
Lac+ are coliforms

7

Name for packaged test kits for Enterobacteriaceae?

Enterotube

8

Three most common causes of foodbourne outbreaks?

Salmonella
Campylobacter
Shigella

9

Relationship of Enterobacteriaceae to endocrine system

Gut bacteria can respond to stress-induced neuroendocrine hormone levels

10

How do bacteria avoid immune response?

Subvert response to avoid detection

11

How can E. Coli be detected on agar?

Copious acid production detected by green metallic sheen on EMB agar

12

Three general clinical syndromes that come from E. Coli

Enteric/Diarrheal Disease
Urinary Tract Infections
Sepsis/Meningitis

13

Most common extraintestinal E. Coli infections?

UTI via UPEC

14

Two ways that E. coli may lead to UTI

Acquire from proximity of anus to urethral meatus
From increased sexual activity (honeymoon cystitis)

15

UPEC is associated with the __ Pilus

P

16

What does EPEC stand for?
What does it do?

Enteropathogenic
Intimin attached protein, bundle formed pili
Efface small intestine microvilli and inhibit water uptake

17

Medical effects of EPEC?
Who gets it?

Watery, self-limiting diarrhea
Esp. Young Children

18

What does ETEC stand for? Nickname?
Medical side effects?

Enterotoxigenic. "Traveler's Diarrhea"
Watery diarrhea, increased gut motility, ab cramps

19

ETEC is associated with what pili?

CFA adhesion pili for brush-border membrane

20

What toxins are produced by ETEC?

2 LT Toxins (LT1 like cholera, higher cAMP)
2 ST toxins (activates cGMP)

21

What does EHEC stand for?
Medical side effects?

Enterohemorrhagic
Bloody diarrhea without fever
Hemolytic-Uremic Syndrome

22

How does EHEC mediate medical effects?

Verotoxin (Shiga-like) -- AB toxin protein synthesis inbititor

23

What is Hemolytic-Uremic Syndrome?
Treatment?

Uremia and organ failure due to glomerular damage
NO anti-biotics -- they induce stx gene

24

What is EIEC?
Medical effects?

Enteroinvasive
Bloody fever with fever

25

EIEC is Indistinguishable from...

Shigella dysenteriae type I

26

Factors produced by EIEC?

Invasive colonization factors

27

What is EAEC?
Medical Effects?

Enteroaggregative
Noninflamatory pediatric diarrhea caused by biofilm development

28

E. coli K1 is a major cause of...

neonatal meningitis

29

Why is E. coli K1 not a good antibody target?

Molecular mimic of host NCAM receptors

30

Who is E. coli K1 especially dangerous to?

low birthweight infants