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renal > BPH > Flashcards

BPH Flashcards

1
Q

zonal anatomy of the prostate (4)

A
  1. transition zone
  2. central zone
  3. peripheral zone
  4. anterior fibromuscular stroma
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2
Q

what zone surrounds the urethra?

A

transition zone

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3
Q

which zone gives rise to BPH?

A

transition zone

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4
Q

what zone surrounds the ejaculatory ducts?

A

central zone

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5
Q

most (____)cancers arise from which zone?

A

70%; peripheral zone

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6
Q

obstructive (voiding) sx assc’d with BPH (4)

A
  1. weak stream
  2. intermittent flow
  3. straining to urinate
  4. incomplete emptying
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7
Q

irritative (storage) sx assc’d with BPH (3)

A
  1. frequency
  2. urgency
  3. nocturia
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8
Q

what can be a sign associated with BPH?

A

hematuria

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9
Q

what converts free testosterone to DHT?

A

5 alpha reductase

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10
Q

utilizations of DRE for BPH

A
  1. estimate size of prostate
  2. assess for prostate nodule suspicious for cancer rectal mass
  3. assess anal sphincter tone
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11
Q

what is the normal size of the prostate?

A

20 gr

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12
Q

what is decision to tx BPH based on?

A

patients level of bother and willingness to comply with tx

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13
Q

what is the target of alpha antags in tx of BPH

A

relaxes prostate and bladder neck smooth muscle tone

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14
Q

which alpha antags are selective? (3)

A
  1. alfuzosin
  2. tamulosin
  3. silodosin
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15
Q

MOA: prevents conversion of testosterone to DHT

A
  1. finasteride

2. dutasteride

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16
Q

what did the MTOPS trial show?

A

combo tx more effective in reducing BPH progression

17
Q

absolute indications for surgery (5)

A
  1. acuter urinary retention
  2. recurrent uti
  3. refractory gross hematuria
  4. bladder stones
  5. azotemia
18
Q

what is the gold standard surgery for BPH

A

transurethral resection of prostate (TURP)

renal (27 decks)

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