Brachyspira

Question 1

Brachyspira and Treponema are known as ____

Answer 1

spirochetes

Question 2

Brachyspira belongs to the family ____ and are obligate _____

Answer 2

family Spirochaetaceae

Obligate anaerobes

Question 3

what part of the body does Brachyspira colonize?

Answer 3

large intestine

*mainly colon

Question 4

What is the most important species of Brachyspira?

Answer 4

Brachyspira Hyodyseneriae

Question 5

What does Brachyspira hyodysenteriae cause and in what animal?

Answer 5

Swine Dysentery

*affects actively growing pigs

Question 6

What makes the Brachyspira cell wall different?

Answer 6

has a lipo-oligosaccharide

Question 7

Brachyspira contains Hemolysin. The more ____ the bacteria, the more chance that it will be associated with bad disease

Answer 7

hemolytic

Question 8

Brachyspira Hyodysenteriae is strongly ____ hemolytic

Answer 8

beta

Question 9

What virulence factor is necessary for Brachyspira and allows the bacteria to move through intestinal mucosa?

Answer 9

flagella

Question 10

What are the most important reservoir for Brachyspira hyodysenteriae?

Answer 10

asymptomatic carrier pigs

Question 11

How is Brachyspira transmitted?

Answer 11

fecal-oral

Question 12

what is the pathogenesis for Brachyspira?

Answer 12

edema, hypermia, hemorrhages

if the infection is bad enough it can lead to failure of colonic absorption

Question 13

What is the major clinical sign of Brachyspira?

Answer 13

Diarrhea

*normally bloody because of damage to enterocytes

Question 14

What are the differentials for Brachyspira Hyodysenteriea that are hard to differentiate?

Answer 14

Salmonellosis and Lawsonia intracellularis

Question 15

What species of Brachyspira causes avian intestial spirochaetosis?

Answer 15

B. pilosicoli

Question 16

Fecal samples for diagnosis of Brachyspira should not be allowed to ___

Answer 16

dry out

Question 17

What is the special blood agar for Brachyspira?

Answer 17

BJ agar

*specific agar with several antibiotics incoorporated

Question 18

The more virulent the strain of Brachyspira, the more ____ on blood agar

Answer 18

hemolytic

Question 19

What disease does Lawsonia Intracellularis cause?

Answer 19

proliferative enteropathy

*in many different species, but mainly porcine

Question 20

Lawsonia intracellularis are ____intracellular pathogens of enterocytes

Answer 20

obligate

Question 21

What type of secretion system does Lawsonia have?

Answer 21

Type 3

Question 22

What are the reservoirs for Lawsonia?

Answer 22

intestinal tract and environment

Question 23

How is Lawsonia transmitted?

Answer 23

fecal oral route

Question 24

what is requires for Lawsonia to be infective?

Answer 24

interaction with unknown natural flora are required for disease

*If the animal has no bacteria in the GI tract then Lawsonia cannot cause disease

Question 25

Lawsonia inhibits the host cell ____ process

Answer 25

maturation \*leads to more bacterial cells and proliferative lesions in the enteric mucosa

Question 26

What antibody is predominant in Lawsonia infections?

Answer 26

IgA

Question 27

True/False: vaccines work well against Lawsonia

Answer 27

True \*vaccines and antibiotics are effective against lawsonia

Question 28

What bacteria causes rabbit syphilis?

Answer 28

Treponema Paraluiscuniculi