Francisella is an obligate ____ bacteria
Best agar to grow Francisella on?
Glucose Cysteine blood agar
*however it is very fastidious and hard to grow in labratory
Is Francisella Tularensis reportable?
What disease does Francisella Tularensis cause?
*highly infectious and affects a wide range of animals
What species of Francisella affects aquatic animals?
Which form of Francisella is considered a potential bioweapon?
Francisella Tularensis subsp. Tularensis
*high virulence, low inectious dose, aerosol dissemination
What virulence factor does Francisella use to attach to macrophages in order to be phagocytosed?
*Francisella wants to be phagocytized by macrophages
What growth loci do Francisella have as part of their pathogenicity islands?
intracellular growth locus
macrophages growth locus
What type of secretion system does Francisella use?
Type 6 secretion system
What is the reservoir for Francisella?
Lagomorphs (rabbits) and rodents
How is Francisella transmitted?
*Dermacentor variabilis (brown dog tick), Dermacentor andersoni (Rocky Mountain wood tick) and Amblyomma americanum ( Lone star tick)
Is Francisella zoonotic?
*humans can get Tularemia
What species is most affected by Tularemia and a potential way for humans to get the pathogen?
What is the most common form of Tularemia?
*when an infected tick bites a host
(other forms include oculoglandular, pneumonic, oropharyngeal, gastrointestinal, and thypoidal)
How is Ulceroglandular tularemia acquired?
What is the most dangerous form of Tularemia?
*also referred to as pneumonic
What system in the body is Tularemia infecting?
True/False: the clinical signs with Tularemia depends on how you acquired the bacteria
*possible fever, headache, pneumonia
Francisella survives and replicates inside ____
Francisella leads to a ______ inflammation in the liver, spleen, and lymph nodes
Tularemia looks similar to _____ because it causes abcesses within the _____
causes abscesses within the lungs
Francisellas ability to survive ____ is crucial for its pathogenesis
Primary target cell for Francisella is _____
What kind of immunity is needed for Francisella?
True/False: Francisella is not reportable
What is the best treatment and control for Tularemia?
antimicrobials- very effective
control of tick population
What fish species are infected by Francisella most often?
tilapia, cod, bass
*warm and cold water fish as well as marine and fresh water
What cells of the fish does Francisella replicate in?
macrophages and monocytes
What kind of inflammation does Francisella cause in fish?