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Flashcards in Francisella Deck (29):
1

Francisella is an obligate ____ bacteria 

aerobic 

2

Best agar to grow Francisella on?

Glucose Cysteine blood agar

*however it is very fastidious and hard to grow in labratory 

3

Is Francisella Tularensis reportable?

Yes!!

4

What disease does Francisella Tularensis cause?

Tularmeia

*highly infectious and affects a wide range of animals 

5

What species of Francisella affects aquatic animals?

Francisella Noatunesis 

6

Which form of Francisella is considered a potential bioweapon?

Francisella Tularensis subsp. Tularensis

*high virulence, low inectious dose, aerosol dissemination 

7

What virulence factor does Francisella use to attach to macrophages in order to be phagocytosed?

Mannose

*Francisella wants to be phagocytized by macrophages 

8

What growth loci do Francisella have as part of their pathogenicity islands?

intracellular growth locus

macrophages growth locus 

9

What type of secretion system does Francisella use?

Type 6 secretion system 

10

What is the reservoir for Francisella?

Lagomorphs (rabbits) and rodents

11

How is Francisella transmitted?

Ticks

*Dermacentor variabilis (brown dog tick), Dermacentor andersoni (Rocky Mountain wood tick) and Amblyomma americanum ( Lone star tick)

12

Is Francisella zoonotic?

Yes

*humans can get Tularemia 

13

What species is most affected by Tularemia and a potential way for humans to get the pathogen?

Cats 

14

What is the most common form of Tularemia?

Ulceroglandular 

*when an infected tick bites a host

(other forms include oculoglandular, pneumonic, oropharyngeal, gastrointestinal, and thypoidal)

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15

How is Ulceroglandular tularemia acquired?

Tick bite 

16

What is the most dangerous form of Tularemia?

Pulmonary 

*also referred to as pneumonic

17

What system in the body is Tularemia infecting?

respiratory system 

18

True/False: the clinical signs with Tularemia depends on how you acquired the bacteria

True 

*possible fever, headache, pneumonia 

19

Francisella survives and replicates inside ____ 

phagocytes 

20

Francisella leads to a ______ inflammation in the liver, spleen, and lymph nodes

pyogranulomatous 

21

Tularemia looks similar to _____ because it causes abcesses within the _____

tuberculosis

causes abscesses within the lungs 

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22

Francisellas ability to survive ____ is crucial for its pathogenesis 

intracellularly 

23

Primary target cell for Francisella is _____

macrophages 

24

What kind of immunity is needed for Francisella?

Cell mediated

25

True/False: Francisella is not reportable

False

*REPORTABLE

26

What is the best treatment and control for Tularemia?

antimicrobials- very effective

control of tick population 

27

What fish species are infected by Francisella most often?

tilapia, cod, bass

*warm and cold water fish as well as marine and fresh water

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28

What cells of the fish does Francisella replicate in?

macrophages and monocytes 

29

What kind of inflammation does Francisella cause in fish?

granulomatous 

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