Flashcards in BRS- Onc Deck (85)
Leading cause of death from disease in childhood?
Most common childhood cancer?
Most common solid childhood cancer?
Cancer= leading cause of death from disease
Childhood cancer = ALL
Solid childhood cancer= brain tumors
Two immunodeficiencies that predispose kiddos to cancer
-Wiskott Aldrich: lymphomas & leukemias
-X linked lymphoproliferative disease: EBV --> lymphoma
EBV assc cancer?
HIV assc cancer?
EBV --> Burkitts
HIV --> Kaposci's
Downs syndrome assc cancers
Syndrome assc with GI cancers
NF II assc cancer
Two abdominal mass types
Neuroblastoma (crosses midline)
Soft mass on extremities
Early morning H/A + vomiting cause
Tumor causing leukocoria
Tumors causing HTN
Peak incidence/ prototype patient with ALL
-white male age 2-6 years
Two classification types for ALL
-immunophenotype (+/- CALA)
Describe cell morphology types + which is most common in ALL?
L1: small with little cytoplasm
L3: large lymphoblasts
*L1 more common
Describe immunophenotypes in ALL + which is most common?
T/B/PreB cell +/- CALLA
Most common Pre B cell + CALLA
What does CALA stand for?
common acute lymphocytic leukemia antigen
Most common ALL symptoms?
fever and bone pain
CBC Findings in ALL
variable WBC count
**CBC does not rule out leukemia
**Must confirm with marrow evaluation
Staging for ALL
no staging system
Favorable age, sex, race for ALL prognosis
Favorable immunophenotype/genetic makeup for ALL:
Three stages of ALL management
What drug is given to all ALL patients in the induction stage of treatment?
What is the consolidation phase of ALL treatment and what is its purpose?
How long is maintenance phase of ALL tx?
cranial irradiation, high risk 5+
**prevents CNS involvement**
-maintenance up to 3 years
Lab findings assc with tumor lysis syndrome
-^^uric acid, ^^potassium, ^^phospohate (=low Ca)
Three sequelae of tumor lysis syndrome
Overall ALL survival rate
Four syndromes assc with AML
What are the 7 types of AML
M1: acute myeloblastic, immature
M2: acute myeloblastic, mature
M3: acute promyelocytic
M4: acute myelomonocytic
M5: acute monocytic
M7: acute megakaryotic