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Flashcards in BRS- Onc Deck (85)
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1

Leading cause of death from disease in childhood?
Most common childhood cancer?
Most common solid childhood cancer?

Cancer= leading cause of death from disease
Childhood cancer = ALL
Solid childhood cancer= brain tumors

2

Two immunodeficiencies that predispose kiddos to cancer

-Wiskott Aldrich: lymphomas & leukemias
-X linked lymphoproliferative disease: EBV --> lymphoma

3

EBV assc cancer?
HIV assc cancer?

EBV --> Burkitts
HIV --> Kaposci's

4

Downs syndrome assc cancers

ALL, AML

5

Syndrome assc with GI cancers

Blooms syndrome

6

NF II assc cancer

acoustic neuroma

7

Two abdominal mass types

Wilms Tumor
Neuroblastoma (crosses midline)

8

Soft mass on extremities

rhabdomyosarcoma

9

Early morning H/A + vomiting cause

brain mass

10

Tumor causing leukocoria

Retinoblastoma

11

Tumors causing HTN

Neuroblastoma
Wilms tumor
Pheochromocytoma

12

Peak incidence/ prototype patient with ALL

-white male age 2-6 years

13

Two classification types for ALL

-cell morphology
-immunophenotype (+/- CALA)

14

Describe cell morphology types + which is most common in ALL?

L1: small with little cytoplasm
L2: between
L3: large lymphoblasts

*L1 more common

15

Describe immunophenotypes in ALL + which is most common?

T/B/PreB cell +/- CALLA
Most common Pre B cell + CALLA

16

What does CALA stand for?

common acute lymphocytic leukemia antigen

17

Most common ALL symptoms?

fever and bone pain

18

CBC Findings in ALL

low platelets
anemia
variable WBC count
**CBC does not rule out leukemia
**Must confirm with marrow evaluation

19

Staging for ALL

no staging system

20

Favorable age, sex, race for ALL prognosis

-2-9
-female
-Caucasian

21

Favorable immunophenotype/genetic makeup for ALL:

+CALLA
-t(9,22)

22

Three stages of ALL management

-induction
-consolidation
-maintenance

23

What drug is given to all ALL patients in the induction stage of treatment?

intrathecal MTX

24

What is the consolidation phase of ALL treatment and what is its purpose?

How long is maintenance phase of ALL tx?

intrathecal MTX
cranial irradiation, high risk 5+
**prevents CNS involvement**

-maintenance up to 3 years

25

Lab findings assc with tumor lysis syndrome

-^^uric acid, ^^potassium, ^^phospohate (=low Ca)

26

Three sequelae of tumor lysis syndrome

-tetany
-renal disease
-cardiac disease

27

Overall ALL survival rate

85%

28

Four syndromes assc with AML

-Fanconi
-Downs
-Kostmann
-Neurofibromatosis

29

What are the 7 types of AML

M1: acute myeloblastic, immature
M2: acute myeloblastic, mature
M3: acute promyelocytic
M4: acute myelomonocytic
M5: acute monocytic
M6: erythroleukemia
M7: acute megakaryotic

30

What are the 4 more common types of AML

M1,2,4,5