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dispensation > cancérologie > Flashcards

cancérologie Flashcards

1
Q

Structure des protéines à activité tyrosine kinase

A

transmembranaire

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2
Q

Quels sont les deux gd moyens pour empêcher une molécule à activité tyrosine kinase de fonctionner

A

utiliser un acmn

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3
Q

Quel est le ma du lapatinib ?

A

empêche l’activation de HER2

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4
Q

Poso du lapatinib

A

une prise par jour en continue, à distance des repas

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5
Q

lapatinib indication

A

en association à la capécitabine au trastuzumab ou à un inhibiteur d’aromatase

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6
Q

métabolisme du lapatinib

A

par le CYP3A4

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7
Q

Ei du lapatinib

A

Diarhée,SMP,eryhtème (tox épidermique)

toxicité cardiaque (car HER2 au niveau cardiaque aussi) et pulmonaire

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8
Q

Citer 4 anti EGFR

A

Erlotinib

Gefetinib

Afatinib

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9
Q

EI des anti EGFR

A

Diarrhée, éruption cutanée (acnéiforme, on donne de la doxy), dyspnée, nausée et vomissement, affection oculaire, aphtes, paronychie.

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10
Q

a quelle classe appartient l’osimertinib ?

A

anti EGFR

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dispensation (34 decks)

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