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Flashcards in Cardiac Drugs Deck (22):
1

What are the two major non-DHP CCBs?

Diltiazem
Verapamil

2

What is the MOA of CCB (what type of Ca channels are blocked, and what is the physiological effect)?

-Block L type Ca channels
-Reduces muscle contractility

3

What is the MOA of hydralazine? Use? Side effects?

-Increase in cGMP to cause smooth muscle relaxation, and vasodilation of *arterioles*
-Used for HTN, CHF
-Lupus-like syndrome

4

What is the MOA of nitroprusside? Use? Side effects?

-Increases cGMP via direct release of NO
-HTN emergency
-Cyanide toxicity

5

What is the MOA of fenoldopam? Use? Side effects?

-Dopamine D1 agonist to cause arteriole vasodilation
-Emergent HTN

6

What is the MOA of NTG? Use? Side effects?

-Vasodilation by increasing NO in vascular smooth muscle, to dilate *veins*
-Pulmonary edema, angina
-Reflex tach, hypotension, HA

7

What is the MOA of statins? Use? Side effects?

-inhibit HMG-CoA reductase
-Hypercholesterolemia
-myopathy / rhabdomyolysis

8

What is the MOA of niacin? Use? Side effects?

-Inhibits lipolysis in adipose tissue
-Reduce VLDL synthesis
-hyperglycemia and hyperuricemia

9

What is the MOA of cholestyramine? Use? Side effects?

-Bile acid resin; prevents intestinal reabsorption of bile acids
-hypercholesterolemia
-Increase in triglycerides, cholesterol gallstones

10

What is the MOA of colestipol? Use? Side effects?

-Bile acid resin; prevents intestinal reabsorption of bile acids
-hypercholesterolemia
-Increase in triglycerides, cholesterol gallstones

11

What is the MOA of colesevelam? Use? Side effects?

-Bile acid resin; prevents intestinal reabsorption of bile acids
-hypercholesterolemia
-Increase in triglycerides, cholesterol gallstones

12

What is the MOA of ezetimibe? Use? Side effects?

-Prevent cholesterol absorption at small intestine brush border
-Increases LFTs, diarrhea

13

What is the MOA of fibrates (-"fibrate")? Use? Side effects?

-Upregulate LPL to increase TG clearance via PPARalpha
-Hypercholesterolemia and hypertriglyceridemia
-Myositis (especially with statins)

14

What is the effect on LDL, HDL, and TGs for: statins

LDL = super decrease
HDL = increase
TG = decrease

15

What is the effect on LDL, HDL, and TGs for: niacin

LDL = Decrease
HDL = good increase
TG = decrease

16

What is the effect on LDL, HDL, and TGs for: Bile acid resins

LDL = Decrease
HDL = slightly increase
TG = slightly increase

17

What is the effect on LDL, HDL, and TGs for: ezetimibe

LDL = Decrease
HDL = none
TG = none

18

What is the effect on LDL, HDL, and TGs for: fibrates

LDL = decrease
HDL = increase
TG = super decrease

19

What is the MOA of digoxin? Use? Side effects?

-Blocks Na/K ATPase to increase Ca inside myocytes, and thereby increase contractility
-CHF and a-fib
-Cholinergic s/sx

20

What are the s/sx of digoxin intoxication?

-Halos around lights
-Yellow vision
-arrhythmias

21

What is the treatment for digoxin intoxication?

"Digibind"-(Anti Fc antibody for digoxin)
-Correct metabolic disturbances
-Mg

22

What are the general MOA of class I - IV antiarrhythmics?

1 = Na blocker
2 = beta blocker
3 = K blocker
4 = CCB