Immunology II (pg 208+) Flashcards Preview

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Flashcards in Immunology II (pg 208+) Deck (74)
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1

What is type I hypersensitivity rxn?

Free antigen cross linking on IgE on mast cells and basophils

2

What causes the delayed type I hypersensitivity rxn?

Production of arachidonic acid metabolites

3

What is the type II hypersensitivity rxn?

Cytotoxic = IgM and IgG bind to fixed antigen on other cells, leading to cellular destruction

4

What are the two types of C regions on the light chains of abs?

*Kappa* and lambda

5

What are the C regions of the heavy chain of Abs?

Part for specificity of IgA, IgG etc.

6

What are the 3 MOA of type II hypersensitivity?

-Opsonization leading to phagocytosis
-Complement mediated lysis
-Antibody-dependent, cell mediated cytotoxicity

7

What is the direct Coomb's test?

detects antibodies that have adhered to patient's RBCs (e/g/ test an Rh + infant of an Rh - mother)

8

What is the indirect Coomb's test?

Detects antibodies that can adhere to other RBCs (e.g. test an Rh - woman for Rh + abs)

9

What is the MOA of papain on abs? Pepsin?

Papain = breaks Fc from variable region and light chains apart
Pepsin = breaks Fc from variable region

10

What is the Arthus rxn?

a local subacute antibody mediated type III reaction

11

What is type IV hypersensitivity rxn?

Delayed type--sensitized T lymphocytes encounter antigen, and then release lymphokines--no ab involved

12

What are the four T's of type IV hypersensitivity rxns?

T lymphocytes
Transplant rejections
TB skin test
Touching (contact dermatitis)

13

What are the components of the ACID mnemonic that describes that four types of hypersensitivity rxns?

-Anaphylactic and atopic
-Cytotoxic (antibody mediated)
-Immune complexes
-Delayed

14

Name the type of hypersensitivity reaction involved: autoimmune hemolytic anemia

II

15

Name the type of hypersensitivity reaction involved: SLE

III

16

Name the type of hypersensitivity reaction involved: MS

IV

17

Name the type of hypersensitivity reaction involved: ITP

II

18

Name the type of hypersensitivity reaction involved: polyarteritis nodosa

III

19

Name the type of hypersensitivity reaction involved: Guillian barre

Iv

20

Name the type of hypersensitivity reaction involved: erythroblastosis fetalis

II

21

Name the type of hypersensitivity reaction involved: post streptococcal GMN

III

22

Name the type of hypersensitivity reaction involved: serum sickness

III

23

Name the type of hypersensitivity reaction involved: arthus rxn

III

24

Name the type of hypersensitivity reaction involved: goodpasture

II

25

Name the type of hypersensitivity reaction involved: Bullous pemphigoid

II

26

Name the type of hypersensitivity reaction involved: pemphigus vulgaris

II

27

Name the type of hypersensitivity reaction involved: GVHD

IV

28

Name the type of hypersensitivity reaction involved: PPD test

IV

29

Name the type of hypersensitivity reaction involved: contact dermatitis

IV

30

Name the type of hypersensitivity reaction involved: rhinitis

I