Immunology II (pg 208+) Flashcards Preview

FA Review > Immunology II (pg 208+) > Flashcards

Flashcards in Immunology II (pg 208+) Deck (74):
1

What is type I hypersensitivity rxn?

Free antigen cross linking on IgE on mast cells and basophils

2

What causes the delayed type I hypersensitivity rxn?

Production of arachidonic acid metabolites

3

What is the type II hypersensitivity rxn?

Cytotoxic = IgM and IgG bind to fixed antigen on other cells, leading to cellular destruction

4

What are the two types of C regions on the light chains of abs?

*Kappa* and lambda

5

What are the C regions of the heavy chain of Abs?

Part for specificity of IgA, IgG etc.

6

What are the 3 MOA of type II hypersensitivity?

-Opsonization leading to phagocytosis
-Complement mediated lysis
-Antibody-dependent, cell mediated cytotoxicity

7

What is the direct Coomb's test?

detects antibodies that have adhered to patient's RBCs (e/g/ test an Rh + infant of an Rh - mother)

8

What is the indirect Coomb's test?

Detects antibodies that can adhere to other RBCs (e.g. test an Rh - woman for Rh + abs)

9

What is the MOA of papain on abs? Pepsin?

Papain = breaks Fc from variable region and light chains apart
Pepsin = breaks Fc from variable region

10

What is the Arthus rxn?

a local subacute antibody mediated type III reaction

11

What is type IV hypersensitivity rxn?

Delayed type--sensitized T lymphocytes encounter antigen, and then release lymphokines--no ab involved

12

What are the four T's of type IV hypersensitivity rxns?

T lymphocytes
Transplant rejections
TB skin test
Touching (contact dermatitis)

13

What are the components of the ACID mnemonic that describes that four types of hypersensitivity rxns?

-Anaphylactic and atopic
-Cytotoxic (antibody mediated)
-Immune complexes
-Delayed

14

Name the type of hypersensitivity reaction involved: autoimmune hemolytic anemia

II

15

Name the type of hypersensitivity reaction involved: SLE

III

16

Name the type of hypersensitivity reaction involved: MS

IV

17

Name the type of hypersensitivity reaction involved: ITP

II

18

Name the type of hypersensitivity reaction involved: polyarteritis nodosa

III

19

Name the type of hypersensitivity reaction involved: Guillian barre

Iv

20

Name the type of hypersensitivity reaction involved: erythroblastosis fetalis

II

21

Name the type of hypersensitivity reaction involved: post streptococcal GMN

III

22

Name the type of hypersensitivity reaction involved: serum sickness

III

23

Name the type of hypersensitivity reaction involved: arthus rxn

III

24

Name the type of hypersensitivity reaction involved: goodpasture

II

25

Name the type of hypersensitivity reaction involved: Bullous pemphigoid

II

26

Name the type of hypersensitivity reaction involved: pemphigus vulgaris

II

27

Name the type of hypersensitivity reaction involved: GVHD

IV

28

Name the type of hypersensitivity reaction involved: PPD test

IV

29

Name the type of hypersensitivity reaction involved: contact dermatitis

IV

30

Name the type of hypersensitivity reaction involved: rhinitis

I

31

What is the pathogenesis and presentation of allergic transfusion rxns?

-type I hypersensitivity rxn against plasma proteins in transfused blood
-Urticaria, pruritus, wheezing, fever

32

What is the pathogenesis and presentation of anaphylactic transfusion rxns?

-Severe allergic rxn, usually d/t IgA deficiency
-Dyspnea, bronchospasm, hypotension, shock

33

What is the pathogenesis and presentation of febrile, nonhemolytic transfusion rxns?

-Type II hypersensitivity rxn; host abs against donor HLA antigens and leukocytes
-Fever, HA, chills, flushing

34

What is the pathogenesis and presentation of acute hemolytic transfusion rxns?

-Type II hypersensitivity rxn that causes intravascular hemolysis. D/t ABO blood group incompatibility.
-Fever, hypotension, tachypnea, tachycardia, flank pain, jaundice

35

What does the Fab determine? Fc?

Fab = Idiotype
Fc = isotype

36

What are the two antibodies that can bind antibodies?

IgG and IgM

37

True or false: antibodies are glycoproteins, and their carbs moieties are attached to the CH2 domain

True

38

How does isotype switching occur?

V(D)J rearrangement

39

What are the autoantibodies in: MG?

anti-ACh receptor

40

What are the autoantibodies in: goodpasture

Anti BM

41

What are the autoantibodies in: SLE, antiphospholipid syndrome

Anti-cardiolipin
Lupus anticoagulant

42

What are the autoantibodies in: CREST (limited scleroderma)

Anticentromere

43

What are the autoantibodies in: SLE

Anti smith
Anti dsDNA
ANA

44

What are the autoantibodies in: DM I

Anti glutamate decarboxylate

45

What are the autoantibodies in: Bullous pemiphgoid

Anti hemidesmosome

46

What are the autoantibodies in: drug induced lupus

anti-histone

47

What are the autoantibodies in: polymyositis and dermatomyositis

Anti Jo
Anti-SRP
Anti-Mi-2

48

What are the autoantibodies in: Hashimoto's thyroiditis

Antimicrosomal
Antithyroglobulin

49

What are the autoantibodies in: primary biliary cirrhosis

Antimitochondrial

50

What are the autoantibodies in: Diffuse scleroderma

Anti SCL-70 (anti DNA topoisomerase I)

51

What are the autoantibodies in: Autoimmune hepatitis

Anti-smooth mucle

52

What are the autoantibodies in: Sjogren's syndrome?

Anti-SSA (ro)
Anti-SSB (la)

53

What are the autoantibodies in: Grave's disease?

Anti TSH

54

What are the autoantibodies in: mixed CT disease?

Anti U1 RNP

55

What are the autoantibodies in: GPA (Wegener's)

c-ANCA

56

What are the autoantibodies in: celiac disease

IgA antiendomysial
IgA anti tissue transglutaminase

57

Which has D chain, light or heavy

Only heavy

58

What are the three segments of the light chain ab?

V
J
C

59

What are the autoantibodies in: microscopic polyangiitis

p-ANCA

60

What are the auto-antibodies in: Churg Strauss syndrome

p-ANCA

61

True or false; light chains have both kappa and lambda light chains

False--either or

62

What is the most abundant light chain?

Kappa chain

63

The variable domain of the light chains is encoded by random recombination of which light chain exon?

V and J

64

What are the autoantibodies in: RA?

Rheumatoid factor
Anti CCP

65

What chromosome has the heavy chain of Abs?

14

66

The first recombination event in heavy chain rearrangement is what?

Between D and J

67

What is the first step of B cell maturation?

Development of heavy chain

68

Which comes first: pro B cells, or Pre B cells?

Pro

69

B cell receptors are membrane bound Ig that are composed of what?

Two heavy and two light chains

70

What is the peaks of serum electrophoresis? (5)

1 = albumin
2 = alpha 1
3 = alpha 2
4 = beta
5 = gamma

71

What are the protein components of MHC class I and II?

I = long alpha and short beta chain
II = Two similar lengths alpha and bet chains (both are membrane spanning)

72

B cells express what CD molecules?

CD 5

73

What is the CD protein that is found on all T cells?

CD3

74

What is the MOA and use of muromonab?

-ANti CD3 ab to prevent T cell activation
-Used for heart and renal transplants