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Flashcards in Celiac Disease Deck (15):
1

immune disorder that is triggered by an environmental agent (the gliadin component in gluten) in genetically predisposed individuals

celiac disease

2

Ethnic group primarily affected by celiac disease

northern Europeans

3

Serologic studies used to confirm the diagnosis of CD

IgA antibodies to gliadin and endomysium

4

Protein triggered by gluten and that controls gut permeability by prying apart the cells of the intestinal lining

zonulin

5

Classic presentation of celiac disease

steatorrhea, weight loss, vitamin deficiencies

6

Seen on small biopsy of patient with celiac disease

villous atrophy

7

T/F Patients with celiac's disease show a decreased risk of breast cancer

true

8

Single preferred test for detection of CD

IgA anti-tissue transglutaminase (TTG)

9

If there is a high probability of the disease, but the IgA anti-tissue transglutaminase (TTG) comes back negative, what further tests can be ordered?

Total IgA or IgG-deaminated gliadin peptides (DGP)

10

What is the next step in the work-up in a patient found to have positive serology?

small bowel biopsy

11

Recommended test for individuals with low pretest probability (purely Chinese, Japanese, and Sub-Saharan African). Is also the most specific test.

IgA endomysial antibody test

12

What is the next step if the serology is positive but the small bowel biopsy is negative?

the patient can be put on high gluten diet and be rebiopsied after6-12 wks

13

Individuals who get diarrhea, feel “ILL” and bloated and find if they eliminate gluten from their diet they feel better

gluten sensitivity

14

presence of what IgA antibody is nearly pathognomonic for CD?

endomysium

15

Recognized incidentally based upon screening for antibodies. Often have some changes in mucosa of the small bowel. do NOT show clinical symptoms but may complain of fatigue

silent CD