Flashcards in Jen's GI pharm Deck (52)
Bind bile acids and inhibit peptic activity. Promote angiogenesis in injured mucosa. Heavy metals suppress H. pylori
General class of pharm treatment that antacids interfere with
Inhibit acid secretion by blocking histamine H2 receptors on the parietal cell
MOA of H2 blockers
Can rarely cause gynecomastia and impotence, oolymyositis, Interstitial nephritis. Cleared through the P450 system so has multiple drug interactions
Prevents chemical induced mucosal damage. Heals chronic ulcers
Binds to the ulcer base best at a pH below 3.5 so should be administered 30-60 min prior to meals
Should not be administered in combination with aluminum antacids in patients with renal failure. No administration w/citrate containing compounds
What is the suffix for all proton pump inhibitors?
What are the generic names for the proton pump inhibitors?
Prilosec, prevacid, protonix, nexium, kapidex, aciphex
MOA of proton pump inhibitors
blocks acid secretion of parietal cells
At what time of day should PPIs be admininstered?
before the first meal of the day
PPI with the lowest potential for P450 drug interactions
PPIs metabolized via CYP2C19 and have the greatest potential for drug interactions
Omeprazole (Prilosec, Zegrid) and esomeprazole (Nexium)
Common blood thinner that has a significant interaction with omeprazole
Long term administration of PPIs may increase the incidence of what two infections
c. difficile and pneumonia
Long term administration of PPIs may lead to the malabsorption of what dietary elements?
B12, Mg+ (magnesium), and Fe (iron)
Suppresses H. pylori infection. Not helpful in treatment of non H pylori induced ulcers
Inhibition of peptic activity but not pepsin secretion. Recruits macrophages to the edge of the ulcer crater to promote healing
First line therapy for gastroparesis for no longer than 12 weeks unless benefits outweigh risks
Improves gastric emptying by increasing gastric antral contractions and decreasing postprandial fundus relaxation
Dopamine receptor antagonist. 5-HT4 agonist. Weak 5-HT3 receptor antagonist
Extrapyradimal side effects associated with metaclopramide (Reglan)
dystonia and tardive dyskinesia
Name the phenothiazines that can be used as antiemetics because of their effects as dopamine receptor antagonists
Prochlorperazine (Compazine) and Promethazine (Phenergan)
What is the treatment for EPS side effects that can be caused by phenothiazines?
Benadryl or Cogentin
Which phenothiazein has a higher incidence of EPS side effects?
Great for postoperative and chemotherapy induced emesis. Does poor job with vestibular system etiology. Commonly given 30" prior to chemo tx.
Serotonin 5-HT3 Antagonists
What is the suffix for Serotonin 5-HT3 Antagonists?
What are the generic names for Serotonin 5-HT3 Antagonists?
Zofran, Kytril, Anzemet, Aloxi
caution for serotonin syndrome, QT prolongation, monitor liver function tests if prolonged use