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Flashcards in Jen's GI pharm Deck (52)
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1

Bind bile acids and inhibit peptic activity. Promote angiogenesis in injured mucosa. Heavy metals suppress H. pylori

antacids

2

General class of pharm treatment that antacids interfere with

antibiotics

3

Inhibit acid secretion by blocking histamine H2 receptors on the parietal cell

MOA of H2 blockers

4

Can rarely cause gynecomastia and impotence, oolymyositis, Interstitial nephritis. Cleared through the P450 system so has multiple drug interactions

Cimetidine

5

Prevents chemical induced mucosal damage. Heals chronic ulcers

Sulcralfate (Carafate)

6

Binds to the ulcer base best at a pH below 3.5 so should be administered 30-60 min prior to meals

Sulcralfate (Carafate)

7

Should not be administered in combination with aluminum antacids in patients with renal failure. No administration w/citrate containing compounds

Sulcralfate (Carafate)

8

What is the suffix for all proton pump inhibitors?

-azole

9

What are the generic names for the proton pump inhibitors?

Prilosec, prevacid, protonix, nexium, kapidex, aciphex

10

MOA of proton pump inhibitors

blocks acid secretion of parietal cells

11

At what time of day should PPIs be admininstered?

before the first meal of the day

12

PPI with the lowest potential for P450 drug interactions

Pantoprazole (Protonix)

13

PPIs metabolized via CYP2C19 and have the greatest potential for drug interactions

Omeprazole (Prilosec, Zegrid) and esomeprazole (Nexium)

14

Common blood thinner that has a significant interaction with omeprazole

clopidogrel (Plavix)

15

Long term administration of PPIs may increase the incidence of what two infections

c. difficile and pneumonia

16

Long term administration of PPIs may lead to the malabsorption of what dietary elements?

B12, Mg+ (magnesium), and Fe (iron)

17

Suppresses H. pylori infection. Not helpful in treatment of non H pylori induced ulcers

Bismuth

18

Inhibition of peptic activity but not pepsin secretion. Recruits macrophages to the edge of the ulcer crater to promote healing

Bismuth

19

First line therapy for gastroparesis for no longer than 12 weeks unless benefits outweigh risks

Metaclopramide (Reglan)

20

Improves gastric emptying by increasing gastric antral contractions and decreasing postprandial fundus relaxation

Metaclopramide (Reglan)

21

Dopamine receptor antagonist. 5-HT4 agonist. Weak 5-HT3 receptor antagonist

Metaclopramide (Reglan)

22

Extrapyradimal side effects associated with metaclopramide (Reglan)

dystonia and tardive dyskinesia

23

Name the phenothiazines that can be used as antiemetics because of their effects as dopamine receptor antagonists

Prochlorperazine (Compazine) and Promethazine (Phenergan)

24

What is the treatment for EPS side effects that can be caused by phenothiazines?

Benadryl or Cogentin

25

Which phenothiazein has a higher incidence of EPS side effects?

Prochlorperazine (Compazine)

26

Great for postoperative and chemotherapy induced emesis. Does poor job with vestibular system etiology. Commonly given 30" prior to chemo tx.

Serotonin 5-HT3 Antagonists

27

What is the suffix for Serotonin 5-HT3 Antagonists?

-setron

28

What are the generic names for Serotonin 5-HT3 Antagonists?

Zofran, Kytril, Anzemet, Aloxi

29

caution for serotonin syndrome, QT prolongation, monitor liver function tests if prolonged use

Odansetron (Zofran)

30

What is the antiemetic that is also good for treating pruritis?

Hydroxyzine (Atarax, Vistaril)