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Flashcards in Cell Wall Inhibitors Deck (57):
0

3 classifications of penicillins

Penicillins
Anti staph penicillins
Extended spectrum penicillins

1

Penicillin moa

Inhibit transpeptidation (cross linking of peptide side chain with pentaglycine bridges in cell wall)

2

Penicillin nucleus

6 amino penicillinic acid nucleus

3

Penicillin whose absorption is not impaired by food intake

Amoxicillin

4

Penicillin na excreted in the bile

Nafcillin

5

Penicillins nae xcreted ink idney and bile

Oxacillin, dicloxacillin and colxacillin

6

No longer used because of acute tubular necrosis

Methicillin

7

Oral form of penicillin

Penicillin v

8

For Mild to moderate staph infections

Isoxazolyl oenicillins - oxacillin, cloxacillin and dicloxacillin

9

For serious staph infections

Oxacillin (in higher doses) and nafcillin

10

Repository forms of penicillin

Benzathine penicillin
Procaine penicillin

11

4 beta lactamase resistant penicillins

Nafcillin
Oxacillin
Dicloxacillin
Methicillin
(Cloxacillin)

12

4 extended spectrum penicillins

Aminopenicillins - amoxicillin, ampicillin, carboxypenicillin ureidopenicillin

13

Penicillin for shigellosis

Ampicillin

14

First anti pseudomonal carboxypenicillin, now obsolete

Carbenicillin

15

Anti pseudomonal penicillins

Carboxypenicillin
Ureidopenicillin (use with aminoglycosides

16

Amoxicillin + clavulanic acid

Augmentin

17

Ampicillin + clavulanic acid

Co amoxiclav

18

Benzathine 1.2 M units is for?

Beta hemolytic strep pharyngitis

19

Benzathine 2.0 M units

Syphilis

20

Cephalosporin nucleus

7-aminocephalosporanic acid

21

First generation cephalosporins

CefAZOLin
CefALEXin
(Azole si alex)

22

Second gen cephalosporin

Cefuroxime
Cefoxitin
Cefmetazole
Cefotetan

23

Third generation cephalosporin

Cefixime
Ceftriaxone
Cefotaxime
Ceftazidime
Cefoperazone
Ceftizoxime

24

Fourth gen cephalosporin

Cefepime

25

Methylthiotetrazole group of cephalosporins

CefAMANDOle
CefMETazole
CefOTEtan
CefOPERAzone

Amando met ote (at the) opera

26

Anti pseudomonal third gen cephalo

Ceftazidime
CefOPERAzone

27

Ceftizoxime clinical use

B. Fragilis

28

DOC for gonorrhea

Cefixime oral
Ceftriaxone parenteral

29

Adverse effects of methylthiotetrazole group

Hypoprothrombinemia
Bleeding
Disulfiram like rxns

30

Monobactams spectrum of activity is limited to

Gram neg rods

31

Monobactam given to allergic to penicillin

Aztreonam

32

3 suicidal inhibitors

Clavulanic acid
Sulbactam
Tazobactam

33

Can stand alone if you want to treat difficult infections

Carbapenems

34

Doc for enterobacter infection

Carbapenem

35

4 carbapenems

Doripenem
Imipenem
Meropenem
Ertapenem

36

Doc for surgical prophylaxis alternative to antistaph penicillins

Imipenem

37

Active only on gram positive except for flavobacterium

Vancomycin

38

4 glycopeptide antibiotics

Vancomycin
Teicoplanin
Telavancin
Dalbavancin

39

Vancomycin indication

For mrsa staph infection

40

Vancomycin only route of administration

Via IV only because it is poorly absorbed

41

2nd doc for c difficile enterocolitis

Vancomycin

42

Vancomycin adr

Red neck syndrome due to histamine release

43

Longer half life than vancomycin but same moa

Teicoplanin

44

Chemically modified vancomycin

Telavancin

45

Chemically modified teicoplanin

Dalbavancin

46

For simple LUTI even for pregnant

Fosfomycin

47

Fosfomycin moa

Inhibits enolpyruvTe transferase

48

Daptomycin moa

Calcium dependent lipid tail insertion forming porin channels that cause k efflux and cell death

49

Moa is to interfere with dephosphorylation in cycling of lipid carrier (c55 isoprenyl pyrophosphate)

Bacitracin

50

Bacitracin use

For surface lesions with mixed flora, topical

51

Inhibits alanine racemase and ligase enzymes

Cycloserine

52

Cycloserine adr

Dose related cns toxicity

53

Third gen cephalosporins that cant cross bbb

Cefoperazone
Cefixime

54

Difference of cephazolin and cephalexin

CephAZOLin is IV
CephALEXin is oral

55

The only second gen cephalosporin that can cross bbb

Cefuroxime axetil

56

Second gen ceph for peritonitis, diverticulitis and anaerobes

Cephamycins -- ceFOXitin, cefOTEtan, cefMETazole