PHARMA anti Cancer Drugs Flashcards Preview

Pharma > PHARMA anti Cancer Drugs > Flashcards

Flashcards in PHARMA anti Cancer Drugs Deck (97):
0

Proteins in control of cell growth

Class i - growth factors
Class ii - Receptors for gf and hormones
Class iii - Intracellular signal transducers
Class iv - Nuclear transcription factors
Class v - Cell cycle control proteins

1

Determines the maximum growth rate of a tumr, not drug sensitivity

Cell cycle time

2

2 ways to classify drugs

1) cell cycle specificity
2) mechanism of action

3

Drugs specific on mitosis

Taxanes, vincas, anti microtubule inhibitor

4

G1 specific drugs

AsparaginSe
Prednisone

5

G1 s specific

Etoposide

6

G1 s specific

Cladribine

7

S lhase specific

Antimetabolites
Hydroxyurea

8

G2 specific

Bleomycin

9

Antimetabolites

Capecitabine
cladribine
cutarabine
fludarabine
gemcitabine
Etc

10

Antitumor antibiotic

Bleomycin

11

Vinca alkaloids

Vinblastine vincristine vinorelbine

12

Epipodophyllotoxins

Etoposide teniposide

13

Taxanes

Paclitaxel docetaxel

14

Alkylating agents (non cell cycle specific)

Busulfan
Carmustine
Cyclophosphamide
Lomustine
Mechlorethamine
Melohalan
Thiotep

15

Anthracyclines (non cell cycle specific)

DaunoRUBICIN
DoxoRUBICIN
EpiRUBICIN
Mitoxantrone

16

Antitumor antibiotics (non cell cycle specific)

Dactinomycin mitomycin

17

Campothecins (non cell cycle specific)

Irinotecan
Topotecan

18

Platinum analogs (non cell cycle specific)

CarboPLATIN
cisPLATIN
oxaliPLATIN

19

Anti parasitic drug combined with anti cancers to enhance biochemical effect

Levamisole

20

Nephrotoxic -

Methotrexate
Cisplatin
Streptozocin

21

Reduce when there is hepatic impairment

Vinca and ??

22

4 general adverse effects of all a ti cancer

Nausea vomiting
Mucositis stomatitis
Baldness
Myelosuppression

23

Alkylating agents

Nitrogen mustard
Ethylenimine
Alkyl sulfonate
Triazene
Platinum

24

Niyrosoureas

CarMUSTINE
loMUSTINE
seMUSTINE
Streptozocin - newest

25

Anti metabolites

Anti folic a id, antipurine, Nti pyrimidines

26

Antibiotics

Anthracyclines - rubicin
DactinoMYCIN
plicamycin
Mitomycin
Bleomycin

27

Hormonal

Tamoxifen
Flutamidd
Gnrh Agonists
Aromatase inhibitors

28

Natural produ ts

Vinca alkaloids
Epipodophyllotoxin
Camptothecins
Taxanes

29

Misc

Amifostine
Hydroxyurea
Etc

30

Alkylating agents MOA

Nucleotides to DNA
Attachment of alkyl groups to DNA bases to form fragmented DNA s

Can also form cross bridges and cause mispairing

31

With direct vessicant effects

Alkylating agents esp nitrogen mustards.. Can damage tissues so give drug very slowly

32

Alkylating agents na irritant

Cisplatin
Dacarbazine

33

Cyclophosphamide clinical use

Breast, leukemias

34

Chlorambucil

Chronic lymphocytic leukemia

35

Busulfan

Chronic myeloid leukemia

36

Oxaliplatin

Colon CA

37

Hematopoietic toxicity of cyclophosphamide ifosfamide

Platelet sparing

38

Hematopoietic toxicity of busulfan

Relative lymphocyte sparing

39

Carboplastin Hematopoietic toxicity of
Cisplatin.

More of platelets

40

Cyclophosphamide GIT ae

Severe NV

41

Busulfan AE

Interstitial pneumonitis, fibrosis

42

Cyclophosphamide ae

Alopecia

43

Nephrotoxic alkylating agents

Cysplatin
Carboplatin
Cyclophosphamide

44

Ototoxic

Cisplatin
Carboplatin IRREVERSIBLE

45

Neuropathy AE

Cisplatin
Oxaliplatin REVERSIBLE

46

NITROSOUREAS moa

Bifunctional alkylating agent capable of alkylation and carbamoylation

47

Only one that can pass BBB in great amounts, with delayed myelosuppressive AEs..

Nitrosoureas

48

Nitrosourea na irritant and pulmonary side effects

Carmustine

49

For insulin secreting islet cell pancreatic carcinoma non hodgkins lymphoma

Strepto??

50

anti folate example

Methotrexate

51

Pyrimidine analogs

Fluoroura capecitabine

52

Anti ppurine

Thioguanine
Mercaptopurine

53

Antimetabolites with both oral and iv preps

Methotrexate
Mercaptopurine

54

Methotrexate

Acute lymphocytic leukemia

55

Mercaptopurine

Childhood acute leukemia

56

5FU

Breast and colorctal

57

Cytarabine

Acute myelogenous leukemia

58

Methotrexate ae

Megaloblastic anemia

59

Methotrexate 5FU and Cytarabine AE

Megaloblastic anemia

60

Act primarily through their effect on microtubular protein wti ha resultant metaphase arrest and inhibition of mitosis

Natural products (mitotic disrupters)

61

Most common AE of natural products

AREFLEXIA (neurotoxic)

62

Vincristine use

ALL

63

Microtubule polymer stabilizers

Taxanes - paclitaxel, docetaxel

64

Toxicity of microtubule polymer stanilizer

Bone marrow suppression

65

Paclitaxel use

Breast ca

66

Epipodophyllotoxins MOA

Topoisomerase ii inhibitors

67

Topoisomerase iii nhibitors AE

Diarrhea

68

Etoposide use

Lung ca

69

Teniposide use

Acute lymphoblastic leukemia

70

Camptothecins use

Inhibit topoisomerase i

71

Topootecan use

Lung

72

Irinotecan

Colorectal ca

73

Most common anthracycline antibiotic

Doxorubicin

74

Antibiotic that can cross bbb a little

Bleomycin

75

Antibiotics ae doxorubicin daunorubicin

Cardiotoxicity

76

Bleomycin ae

Pulmonary fibrosis

77

Plicamycin

Hepatotoxicity

78

Antibiotics moa

Blocks dna to rna

79

Doxorubicin use

Marami

80

Androgen antagonist

Flutamide

81

Estrogen antagonist

Tamoxifen

82

Aromatase inhibitor

Anastrozole

83

Gnrh inhibitor

Leuprolide

84

Peptide hormone inhibitor

Octreotide

85

Tampxifen

Breast ca

86

Flutamide

Prostatic ca

87

Anastrozole

advanced er pr + ?

88

Flutamide ae

Hot flashes impotence libido

89

Fluoxymestetone

Chooestatic jaundice

90

Cytoprotective from effects of cisplatin

Amifostine

91

Colon cancer drug combinations

Folfiri
Folfox
Capeox
Capeox wi th or without bevacizumab

92

Leukemia ALL drug combi

Vincristine and prednisone
Efc

93

Breast drug combi

CAF
AC
CMFP
Etc

94

Lung drug combi

Etoppside plus cisplatin

95

Aml combi

Cytarabine daunorubicin

96

Helps prevent heart damage

Dexrazoxaone??