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PHARMA anti Cancer Drugs Flashcards

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0
Q

Determines the maximum growth rate of a tumr, not drug sensitivity

A

Cell cycle time

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1
Q

Proteins in control of cell growth

A 
Class i - growth factors
Class ii - Receptors for gf and hormones
Class iii - Intracellular signal transducers
Class iv - Nuclear transcription factors
Class v - Cell cycle control proteins
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2
Q

2 ways to classify drugs

A

1) cell cycle specificity

2) mechanism of action

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3
Q

Drugs specific on mitosis

A

Taxanes, vincas, anti microtubule inhibitor

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4
Q

G1 specific drugs

A

AsparaginSe

Prednisone

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5
Q

G1 s specific

A

Etoposide

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6
Q

G1 s specific

A

Cladribine

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7
Q

S lhase specific

A

Antimetabolites

Hydroxyurea

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8
Q

G2 specific

A

Bleomycin

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9
Q

Antimetabolites

A 
Capecitabine 
cladribine
 cutarabine 
fludarabine 
gemcitabine
Etc
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10
Q

Antitumor antibiotic

A

Bleomycin

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11
Q

Vinca alkaloids

A

Vinblastine vincristine vinorelbine

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12
Q

Epipodophyllotoxins

A

Etoposide teniposide

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13
Q

Taxanes

A

Paclitaxel docetaxel

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14
Q

Alkylating agents (non cell cycle specific)

A 
Busulfan
Carmustine
Cyclophosphamide
Lomustine
Mechlorethamine
Melohalan
Thiotep
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15
Q

Anthracyclines (non cell cycle specific)

A

DaunoRUBICIN
DoxoRUBICIN
EpiRUBICIN
Mitoxantrone

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16
Q

Antitumor antibiotics (non cell cycle specific)

A

Dactinomycin mitomycin

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17
Q

Campothecins (non cell cycle specific)

A

Irinotecan

Topotecan

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18
Q

Platinum analogs (non cell cycle specific)

A

CarboPLATIN
cisPLATIN
oxaliPLATIN

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19
Q

Anti parasitic drug combined with anti cancers to enhance biochemical effect

A

Levamisole

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20
Q

Nephrotoxic -

A

Methotrexate
Cisplatin
Streptozocin

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21
Q

Reduce when there is hepatic impairment

A

Vinca and ??

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22
Q

4 general adverse effects of all a ti cancer

A

Nausea vomiting
Mucositis stomatitis
Baldness
Myelosuppression

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23
Q

Alkylating agents

A 
Nitrogen mustard
Ethylenimine
Alkyl sulfonate
Triazene 
Platinum
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24
Niyrosoureas
CarMUSTINE loMUSTINE seMUSTINE Streptozocin - newest
25
Anti metabolites
Anti folic a id, antipurine, Nti pyrimidines
26
Antibiotics
``` Anthracyclines - rubicin DactinoMYCIN plicamycin Mitomycin Bleomycin ```
27
Hormonal
Tamoxifen Flutamidd Gnrh Agonists Aromatase inhibitors
28
Natural produ ts
Vinca alkaloids Epipodophyllotoxin Camptothecins Taxanes
29
Misc
Amifostine Hydroxyurea Etc
30
Alkylating agents MOA
Nucleotides to DNA Attachment of alkyl groups to DNA bases to form fragmented DNA s Can also form cross bridges and cause mispairing
31
With direct vessicant effects
Alkylating agents esp nitrogen mustards.. Can damage tissues so give drug very slowly
32
Alkylating agents na irritant
Cisplatin | Dacarbazine
33
Cyclophosphamide clinical use
Breast, leukemias
34
Chlorambucil
Chronic lymphocytic leukemia
35
Busulfan
Chronic myeloid leukemia
36
Oxaliplatin
Colon CA
37
Hematopoietic toxicity of cyclophosphamide ifosfamide
Platelet sparing
38
Hematopoietic toxicity of busulfan
Relative lymphocyte sparing
39
Carboplastin Hematopoietic toxicity of | Cisplatin.
More of platelets
40
Cyclophosphamide GIT ae
Severe NV
41
Busulfan AE
Interstitial pneumonitis, fibrosis
42
Cyclophosphamide ae
Alopecia
43
Nephrotoxic alkylating agents
Cysplatin Carboplatin Cyclophosphamide
44
Ototoxic
Cisplatin | Carboplatin IRREVERSIBLE
45
Neuropathy AE
Cisplatin | Oxaliplatin REVERSIBLE
46
NITROSOUREAS moa
Bifunctional alkylating agent capable of alkylation and carbamoylation
47
Only one that can pass BBB in great amounts, with delayed myelosuppressive AEs..
Nitrosoureas
48
Nitrosourea na irritant and pulmonary side effects
Carmustine
49
For insulin secreting islet cell pancreatic carcinoma non hodgkins lymphoma
Strepto??
50
anti folate example
Methotrexate
51
Pyrimidine analogs
Fluoroura capecitabine
52
Anti ppurine
Thioguanine | Mercaptopurine
53
Antimetabolites with both oral and iv preps
Methotrexate | Mercaptopurine
54
Methotrexate
Acute lymphocytic leukemia
55
Mercaptopurine
Childhood acute leukemia
56
5FU
Breast and colorctal
57
Cytarabine
Acute myelogenous leukemia
58
Methotrexate ae
Megaloblastic anemia
59
Methotrexate 5FU and Cytarabine AE
Megaloblastic anemia
60
Act primarily through their effect on microtubular protein wti ha resultant metaphase arrest and inhibition of mitosis
Natural products (mitotic disrupters)
61
Most common AE of natural products
AREFLEXIA (neurotoxic)
62
Vincristine use
ALL
63
Microtubule polymer stabilizers
Taxanes - paclitaxel, docetaxel
64
Toxicity of microtubule polymer stanilizer
Bone marrow suppression
65
Paclitaxel use
Breast ca
66
Epipodophyllotoxins MOA
Topoisomerase ii inhibitors
67
Topoisomerase iii nhibitors AE
Diarrhea
68
Etoposide use
Lung ca
69
Teniposide use
Acute lymphoblastic leukemia
70
Camptothecins use
Inhibit topoisomerase i
71
Topootecan use
Lung
72
Irinotecan
Colorectal ca
73
Most common anthracycline antibiotic
Doxorubicin
74
Antibiotic that can cross bbb a little
Bleomycin
75
Antibiotics ae doxorubicin daunorubicin
Cardiotoxicity
76
Bleomycin ae
Pulmonary fibrosis
77
Plicamycin
Hepatotoxicity
78
Antibiotics moa
Blocks dna to rna
79
Doxorubicin use
Marami
80
Androgen antagonist
Flutamide
81
Estrogen antagonist
Tamoxifen
82
Aromatase inhibitor
Anastrozole
83
Gnrh inhibitor
Leuprolide
84
Peptide hormone inhibitor
Octreotide
85
Tampxifen
Breast ca
86
Flutamide
Prostatic ca
87
Anastrozole
advanced er pr + ?
88
Flutamide ae
Hot flashes impotence libido
89
Fluoxymestetone
Chooestatic jaundice
90
Cytoprotective from effects of cisplatin
Amifostine
91
Colon cancer drug combinations
Folfiri Folfox Capeox Capeox wi th or without bevacizumab
92
Leukemia ALL drug combi
Vincristine and prednisone | Efc
93
Breast drug combi
CAF AC CMFP Etc
94
Lung drug combi
Etoppside plus cisplatin
95
Aml combi
Cytarabine daunorubicin
96
Helps prevent heart damage
Dexrazoxaone??

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