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Flashcards in PHARMA endocrine Drugs Deck (45):
0

Growth hormone side effect

Pseudotumor cerebri (intracranial hpn)
Scoliosis in children
Hyperglycemia

1

Complex of rhIGF 1 and rhIGFBP 3

Mecasermin

2

Most important side effect of Mecasermin

Hypoglycemia

3

Tx for GH resistant cases

Mecasermin

4

Novel GH receptor antagonist, for small gh-secreting adenomas

Pegvisomant (withpolyethyleneglycol)

5

Somatostatin analog

Octreotide

6

Advantage of octreotide vs somatostatin

Octreotide lasts 30x longer

7

Octreotide clinical use

For hormone secreting tumors

8

Diagnostic method to localize neuroendocrine tumors ha ing sst receptor

Somatostatin receptor scintigraphy

9

Other use of octreotide

Aute esophageal varices

10

Approved tx of acromegaly

Lanreotide

11

Human menopausal gonadotropins

Menotropins

12

urofollitropin

FSH

13

Lutropin alfa

Recombinant human LH

14

Choriogonadotropin alfa

Rh cg

15

Gonadotropin clinical use

Anovulation
Female infertility
Hypogonadotropic hypogonadism male infertility
Assisted reproductive therapy

16

Alternative for ovulation induction

Clomiphene

17

Conventional therapy for male infertility

HCG
HMG

18

Characteristics of ovarian hyperstimulation syndrome

Ovarian enlargement
Ascites
Hypovolemia

19

Gnrh pulsatile vs sustained non pulsatile

Pulsatile - stimulate fsh and lh
Sustained non pulsatile - inhibit fsh and lh, for gonadal and ovarian suppression

20

Acetate salt of synthetic human gnRH, pulsatile release

Gonadorelin

21

Synthetic analogs of gnrh

Longer half life

22

Biphasic response to continuous gonadorelin

Flare during first 7-10 days
Then
Receptor down regulation

23

Clinical use of gonadotropin AND gonadorelin

Prevent premature lh surge and ovulation
Etc

24

Endometriosis treatment

Leuprolide and sometng

25

Uterine leiomyomata (fibrosis) treatment

Continuois gnrh agonist with iron supplement for 3-6 months

26

Prostate cancer treatment

Continuous gnrh agonist AND flutamide (androgen antagonist)

27

How to prevent tumor flare of trstosterone

Biclutamide (androgen antagonist)

28

Preferred tx of breast cancer after mastectomy

Tamoxifen in premenopausal
Aromatase inhibitors in postmenopausal

29

Controversial adjuvant tx for breast ca

Ovarian suppression or ovarian ablation

30

Treatment for central precociouspuberty

Leuprolide
Histrelin
Nafarelin

31

Gonadorelin toxicity

Something and Blindness

32

gonadorelin analog in nasal form

Nafarelin

33

Ganirelix
Cetrorelix

Controlled ovarian hyperstimulation

34

Dextrirrlix???

Prostate cancer

35

Dopamine agonists na ergot derivatives

Bromocriptine
Cabergoline

36

Non ergot dopamine agonist

Quinagolide

37

Dopamine agonist with longest duration of action

Cabergoline

38

Dopamine agonist toxicity

Erythromelalgia etc

39

Oxytocin effect at high concentrations

Weak adh action

40

Oxytocin

toxicityexcessive uterine contraction
Excessive Fluid retention
Hypotension

41

Oxytocin antagonist

Atosiban

42

Long acting synthetic analog of vasopressin

Desmopressin

43

Clinical use of desmopressin

Nocturnal enuresis in px with diabetes insipidus

44

Vasopressin antagonist

Conivaptan
Tolvaptan