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Flashcards in PHARMA anti Mycobacterial Deck (11):
0

INH moa

Inhibits mycolic acid synthesis

1

High level resistance of inh

Deletion of kat g gene

2

Low level resistance of inh

Changed inhA gene

3

AhpC virulence gene and kasA mutation cause resistance in?

Isoniazid

4

Drugs that cause sle like symptoms

ISONIAZID
Procainamide
Hydralazine

5

Inh adr

Peripheral neuritis so give pyridoxine
Inc level of phenytoin and carbamazepine

6

Rifampin moa

Inhibits DNA-dependent RNA polymerase

7

Causes harmless red orange metabolites in secretions

Rifampin

8

Resistance emerges rapidly if used alone

Rifampin

9

Inhibits arabinosyltransferase, blocks formation of ARABINOGLYCAN

Ethambutol

10

Dose dependent retrobulbar neuritis

Ethambutol