PHARMA antipsychotics Flashcards Preview

Pharma > PHARMA antipsychotics > Flashcards

Flashcards in PHARMA antipsychotics Deck (44):
1

1 Chlorpromazine (Aliphatic)

A Phenothiazine Derivatives Antipsychotic

2

2 Thioridazine (Piperidine)

A Phenothiazine Derivatives Antipsychotic

3

3 Fluphenazine (Piperazine)

A Phenothiazine Derivatives Antipsychotic

4

1 Haloperidol

B Butyrophenone Derivatives Antipsychotic

5

1 Thiothixene

C Thioxanthene Derivative Antipsychotic

6

1 Pimozide

D Miscellaneous Structures Antipsychotic

7

2 Molindone

D Miscellaneous Structures Antipsychotic

8

1 Clozapine

E Atypical Antipsychotic

9

2 Asenapine

E Atypical Antipsychotic

10

3 Olanzapine

E Atypical Antipsychotic

11

4 Quetiapine

E Atypical Antipsychotic

12

5 Zotepine

E Atypical Antipsychotic

13

6 Paliperidone

E Atypical Antipsychotic

14

7 Risperidone

E Atypical Antipsychotic

15

8 Ziprasidone

E Atypical Antipsychotic

16

9Aripiprazole

E Atypical Antipsychotic

17

10 Sertindole

E Atypical Antipsychotic

18

Earliest to peak

Risperidone 1-1.5 hrs

19

Shortest half life

Risperidone 3-4 hrs

20

Highest Vd

Olanzapine 10-20 L/kg

21

Highest protein binding

Ziprasidone >99%

22

MOA of antipsychotics

antagonist or partial agonist at D2 dopamine receptors

23

Mesolimbic-Mesocortical Pathway

behavior and psychosis

24

Nigrostriatal Pathway

coordination of voluntary movement

25

Tuberoinfundibular Pathway

inhibition of prolactin secretion

26

Medullary Periventricular Pathway

may be involved in eating behavior

27

Incertohypothalamic Pathway

appears to regulate the anticipatory motivational phase of copulatory behavior in rats

28

orthostatic hypotension, impaired ejaculation, deposits in lens

Chlorpromazine

29

deposits in retina; slightest EPS

Thiodiazine

30

tardive dyskinesia

Fluphenazine

31

no weight gain

Loxapine

32

severe EPS; cardiotoxicity (torsades)

Haloperidol

33

EPS

D2

34

Sedation

a1 H1

35

Anticholinergic

M1

36

Orthostatic hypotension

a1

37

Weight gain

5HT

38

Anti emesis

Prochlorperazine

39

Pruritus

Quetiapine

40

Neurolept Anesthesia

Droperidol + Fentanyl

41

1 Carbamazepine

Anticonvulsant under Mood Stabilizing Drugs

42

2 Valproic Acid

Anticonvulsant under Mood Stabilizing Drugs

43

Carbamazepine MOA

inositol inhibition

44

Valproic Acid MOA

inositol inhibition; GSK-3 inhibition