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Flashcards in PHARMA anti Virals Deck (38):
0

Blockers of viral attachment and entry

ENMADOPA
Enfuviritide
Maraviroc
Doconasol
Palivizuma

1

Blocker of penetration

Interferon alpha

2

Blocks uncoating

Amantidine
Rimantidine
(Anti influenzas)

3

Blockers of nuckeid acid synthesis

NRTIs
NNRTIs
Acyclovir
Foscarnet

4

Blockers of late protein synthesis and processing

Protease inhibitors
Ritonavir
Indinavir

5

Blocker of viral release

Neuraminidase inhibitors
Zanavidir
Oselnativir ??

6

Monophosphorylated by thymidine kinase

Acyclovir
Valacyclovir
Famciclovir

7

Acyclovir moa

Competitive inhibition of viral dna polymerase
Chain termination

8

L valyl ester ofadcyclovir with higher bioavailability

Valacyclovir

9

Prodrug of penciclovir that DOES NOT cause chain termination

Famciclovir

10

Topical cream that prevents viral entry

Doconasol

11

Phosphorykated intracellularly by HOST ENZYMES, competes with thymidine triphosphate

Trifluridine

12

Trifluridine use

Keratoconjunctivitis
Keratitis

13

Three anti cmv agents

Ganciclovir
Foscarnet
Cidofovir

14

Phosphorylated by viral PHOSPHOTRANSRASE, fir cmv inducing retinitis

Ganciclovir

15

Not an antimetabolite, blocks pyrophosphate binding sites of enzymes

Foscarnet

16

With activity against tk- strains

Trifluridine
Foscarnet
Cidofovir

17

Cytosine nucleotide analog, potent inhibitor and substrate for viral dna polymerase

Cidofovir

18

Structural analogs that cause COMPETITIVE inhibition of hiv 1 reverse transcriptase

NRTIs

19

5 examples of NRTIs

Zidovudine - prototype
Didanosine - pancreatitis
Zalcitabine - neutropenia
Stavudine - myelosuppression less than azt
Lamivudine - for hepa B

20

Binds directly to reverse transcriptase in an ALLOSTERIC MANNER

NNRTIs

21

2 examples of nnrtis

Delavirdine
Nevirapine

22

Protease inhibitors

Ritonavir
Indinavir

23

PI that increases effect of dronabinol

Ritonavir

24

PI with lesssdideedffects

Indinavir

25

Protease inhibitor side effect

Fat redistribution

26

Entry inhibitors / fusion inhibitors

Enfuvirtide
Maraviroc

27

Binds to gp41 subunit of envelope glycoprotein, can be given SQ

Enfuviritide

28

CCR5 Receptor antagonist, tropism testing needed

Maraviroc

29

Integrase strand transfer inhibitor

Raltegravir

30

HAART A

AZT / zidovudine
D4T / Stavudine

31

HAART B

Didanosine
Zalcitabine
Lamivudine
Emtricitabine
Abacavir

32

HAART C

A PI - ritonavir indinavir
Nnrti - nevirapine delavirdine

33

Anti hepa B and their analogs

LATTE-CATAG
Lamivudine
Adefovir
Telbivudine
Tenofovir
Entecavir

34

For hep c and RSV (?)

Ribavirin

35

Amantidine rimantidine moa

Anti influenza - blocks the m2 proton ion channel of the virus oarticke - INHIBIT UNCOATING

36

Neuraminidase inhibitors - preventing RELEASE

Zanavir
Oseltamavir

37

Oseltamavir vs zanamivir

Oseltamavir ORAL
zanavir INHALATIONAL