PHARMA protein Synthesis Inhibitors

Question 0

Bind to 50s subunit and block TRANSLOCATION (step 2)

Answer 0

Macrolides

Question 1

Bind to 50s subunit and inhibit PEPTIDYLTRANSFERASE

Answer 1

Chloramphenicol

Question 2

Bind to 30s subunit and inhibit binding of incoming charged aminoacyl-tRNA unit to the acceptor site (step 1)

Answer 2

Tetracyclins

Question 3

Inhibit formation of initation complex and misread codes

Answer 3

Aminoglycosides

Question 4

Bind 30s?

Answer 4

Clindamycin

Question 5

Should not be given with bivalent metal ions like antacids

Answer 5

Tetracyclins

Question 6

Give 3 tetracyclins

Answer 6

Minocycline
Doxycycline
Tigecycline

Question 7

Minocycline use

Answer 7

For meningococceal carrier state

Question 8

DOC for patients with renal insufficiencies

Answer 8

Doxycycline

Question 9

Broad spectrum but proteus and p aeruginosa are intrinsically resistant

Answer 9

Tigecycline

Question 10

MLS stands for?

Answer 10

Macrolide
Lincosamide
Streptogramins

Question 11

Inhibitors of cyp3A4

Answer 11

Macrolides and clindamycin

Question 12

Prototypic macrolide drug

Answer 12

Erythromycin

Question 13

Used against gram positive organisms

Answer 13

Erythromycin

Question 14

Most common reason for discontinuing erythromycin

Answer 14

Adr of GI intolerance(erythromycin activates motillin receptors)

Question 15

More active against MAC

Answer 15

Clarithromycin

Question 16

Advantages of clarithromycin over erythromycin

Answer 16

Less gi intolerance

Less frequent dosing

Question 17

Codrug of choice against chlamydia along with doxycycline

Answer 17

Azithromycin

Question 18

Clindamycin + aminoglycoside or cephalosporin

Answer 18

Tx of penetrating wounds of the abdomen or gut

Question 19

Alternative to cotri against moderately severe pneumocystis jiroveci pneumonia in aids patients

Answer 19

Clindamycin + primaquine

Question 20

For aids related toxoplasmosis of the brain

Answer 20

Clindamycin + pyrimethamine

Question 21

Always associated with pseudomembranous enterocolitis

Answer 21

Clindamycin

Question 22

Combination of 2 streptogramins

Answer 22

Quinupristin-Dalfopristin (B and A respectively)

Question 23

MLS type A resistant organisms are resistant to what streptogramin?

Answer 23

Dalfopristin

Question 24

Resistance of chloramphenicol

Answer 24

Transacetylase

Question 25

Approved for tx of infections by staph or vancomycin resistant e. Faecium

Answer 25

Quinupristin dalfopristin

Question 26

Rarely used because it has lots of adrs

Answer 26

Chloramphenicol

Question 27

Gray baby syndrome

Answer 27

Chloramphenicol because babies cant glucoronate chloramphenicol yet

Question 28

Tx for serious rickettsial infections, but not chlamydia

Answer 28

Chloramphenicol

Question 29

Other adrs of chloramphenicol

Answer 29

Gi disturbance | Bone marrow suppression - dose related and fatal aplastic anemia

Question 30

Explain how aminoglycosides can be bacteriostatic and bacteriocidal at the same time

Answer 30

Bacteriostatic - interfere with initiation complex of peptide formation Bacteriocidal - misreading of mrna and coding non functional proteins

Question 31

Resistance by adenylation acetylation phosphorylation etc

Answer 31

Aminoglycosides

Question 32

Oxygen dependent, so cant be used on anaerobics

Answer 32

Aminoglycosides

Question 33

4 reasons why once daily dosing for aminoglycosides is enough

Answer 33

Nephrotoxic Narrow therapeutic range High PAE concentration dependent

Question 34

ADRS of aminoglycosides

Answer 34

``` Nephrotoxic Ototoxic Vestibular dysf NM blockade Contact dermatitis ```

Question 35

Polar, poorly absorbed, always parenteral

Answer 35

Aminoglycosides

Question 36

Most ototoxic aminoglycosides

Answer 36

NKA neomycin Kanamycin Amikacin

Question 37

Most vestibulotoxic aminoglycoside

Answer 37

Streptomycin | Gentamicin

Question 38

Most nephrotoxic aminoglycoside

Answer 38

NTG neomycin Tobramycin Gentamicin

Question 39

Adr contact dermatitis

Answer 39

Neomycin

Question 40

Fifth agent for tb

Answer 40

Streptomycin

Question 41

Causes deafness in newborn if given in pregnancy

Answer 41

Streptomycin

Question 42

Used in severe infections, in IM IV or topical form

Answer 42

Gentamicin

Question 43

Available in inhalational form for p aeruginosa lrti in complicated cystic fibrosis

Answer 43

Tobramycin

Question 44

For topical and oral use only aminoglycoside

Answer 44

Neomycin and kanamycin

Question 45

Alternative tx for drug resistant gonorrhea

Answer 45

Spectinomycin

Question 46

Inhibits protein synthesis by binding to 23s rRNA of 50s subunit

Answer 46

Oxazolinidones

Question 47

Most common adr of linezolid

Answer 47

Thrombocytopenia