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Flashcards in PHARMA protein Synthesis Inhibitors Deck (48):
0

Bind to 50s subunit and inhibit PEPTIDYLTRANSFERASE

Chloramphenicol

1

Bind to 50s subunit and block TRANSLOCATION (step 2)

Macrolides

2

Bind to 30s subunit and inhibit binding of incoming charged aminoacyl-tRNA unit to the acceptor site (step 1)

Tetracyclins

3

Inhibit formation of initation complex and misread codes

Aminoglycosides

4

Bind 30s?

Clindamycin

5

Should not be given with bivalent metal ions like antacids

Tetracyclins

6

Give 3 tetracyclins

Minocycline
Doxycycline
Tigecycline

7

Minocycline use

For meningococceal carrier state

8

DOC for patients with renal insufficiencies

Doxycycline

9

Broad spectrum but proteus and p aeruginosa are intrinsically resistant

Tigecycline

10

MLS stands for?

Macrolide
Lincosamide
Streptogramins

11

Inhibitors of cyp3A4

Macrolides and clindamycin

12

Prototypic macrolide drug

Erythromycin

13

Used against gram positive organisms

Erythromycin

14

Most common reason for discontinuing erythromycin

Adr of GI intolerance(erythromycin activates motillin receptors)

15

More active against MAC

Clarithromycin

16

Advantages of clarithromycin over erythromycin

Less gi intolerance
Less frequent dosing

17

Codrug of choice against chlamydia along with doxycycline

Azithromycin

18

Clindamycin + aminoglycoside or cephalosporin

Tx of penetrating wounds of the abdomen or gut

19

Alternative to cotri against moderately severe pneumocystis jiroveci pneumonia in aids patients

Clindamycin + primaquine

20

For aids related toxoplasmosis of the brain

Clindamycin + pyrimethamine

21

Always associated with pseudomembranous enterocolitis

Clindamycin

22

Combination of 2 streptogramins

Quinupristin-Dalfopristin (B and A respectively)

23

MLS type A resistant organisms are resistant to what streptogramin?

Dalfopristin

24

Resistance of chloramphenicol

Transacetylase

25

Approved for tx of infections by staph or vancomycin resistant e. Faecium

Quinupristin dalfopristin

26

Rarely used because it has lots of adrs

Chloramphenicol

27

Gray baby syndrome

Chloramphenicol because babies cant glucoronate chloramphenicol yet

28

Tx for serious rickettsial infections, but not chlamydia

Chloramphenicol

29

Other adrs of chloramphenicol

Gi disturbance
Bone marrow suppression - dose related and fatal aplastic anemia

30

Explain how aminoglycosides can be bacteriostatic and bacteriocidal at the same time

Bacteriostatic - interfere with initiation complex of peptide formation

Bacteriocidal - misreading of mrna and coding non functional proteins

31

Resistance by adenylation acetylation phosphorylation etc

Aminoglycosides

32

Oxygen dependent, so cant be used on anaerobics

Aminoglycosides

33

4 reasons why once daily dosing for aminoglycosides is enough

Nephrotoxic
Narrow therapeutic range
High PAE
concentration dependent

34

ADRS of aminoglycosides

Nephrotoxic
Ototoxic
Vestibular dysf
NM blockade
Contact dermatitis

35

Polar, poorly absorbed, always parenteral

Aminoglycosides

36

Most ototoxic aminoglycosides

NKA
neomycin
Kanamycin
Amikacin

37

Most vestibulotoxic aminoglycoside

Streptomycin
Gentamicin

38

Most nephrotoxic aminoglycoside

NTG
neomycin
Tobramycin
Gentamicin

39

Adr contact dermatitis

Neomycin

40

Fifth agent for tb

Streptomycin

41

Causes deafness in newborn if given in pregnancy

Streptomycin

42

Used in severe infections, in IM IV or topical form

Gentamicin

43

Available in inhalational form for p aeruginosa lrti in complicated cystic fibrosis

Tobramycin

44

For topical and oral use only aminoglycoside

Neomycin and kanamycin

45

Alternative tx for drug resistant gonorrhea

Spectinomycin

46

Inhibits protein synthesis by binding to 23s rRNA of 50s subunit

Oxazolinidones

47

Most common adr of linezolid

Thrombocytopenia