Cementogenesis - hard tissue development Flashcards
cementum
Derived from ? cells in the ?
ectomesenchymal
dental follicle
what are the two types of cementum?
Acellular -> primary
- Developing normally and slowly
Cellular -> secondary
- Development leads to cementoblasts becoming trapped in the cementum, called cementocytes
- Response to insult
Dental ? -> odontoblasts -> dentine
Dental ? -> cementoblasts -> cementum
Both the dental papilla and follicle are of ? origin but need an ? initiating signal
papilla
follicle
ectomesenchymal
epithelial
The roots form when the ? has formed and begins to ?
crown
erupt
Root development is driven by what?
Hertwig’s epithelial root sheath (HERS)
hertwig’s epithelial root sheath (HERS) is derived from what?
the cervical loop of epithelial cells of the enamel organ
hertwig’s epithelial root sheath (HERS) induces what?
root dentinogenesis and cementogenesis (indirectly)
hertwig’s epithelial root sheath (HERS)
Proliferates ?
Disintegrates ?
apically (down)
cervically (accross)
hertwig’s epithelial root sheath (HERS)
Produces growth factors ?,?,?
transcription factor ?
BMP4
EGF
TGFβ
SHH
Root formation
? induces odontoblast formation ?
? then ? forms and ??? breaks down
? cells secrete enamel matrix proteins (?) on the surface of ?
Enamel matrix proteins mineralise forming the ?????
Hers cells disintegrate ? as no ?? and cant attach to ??
Inductions of ?? to migrate to the ?? and form ?
Cementoblasts secrete ?? and retreat ?
Cementum matrix ?, entrapping ?? (collagen) -> ??
Remnant of HERS form ???? in ? -> ??
HERS
apically
predentine
dentine
HERS basal lamina
HERS
amelogenins
predentine
hyaline layer of hopewell smith
coronally
basal lamina
enamel proteins
follicle cells
root surface
cementoblasts
cementum matrix
outwards
mineralises
PDL fibres
sharpey fibres
cell rests of malassez
PDL
cystic potential
root formation overview
Cementoblasts origin
They are derived from ?? however new evidence suggests that some cementoblasts may be derived from ?? through undergoing ?
dental follicle
HERS cells
epithelial to mesenchymal transformation
When the tooth is unerupted it sits in ? surrounded by ??. The ??? protects the tooth from follicle cells.
If the reduced enamel epithelium is broken exposing the enamel to the follicle cells. The ?? in enamel induces the ?? to migrate and make ?
bone
follicle cells
reduced enamel epithelium
epithelial proteins
follicle cells
cementum
Clinical application of enamel proteins inducing cementogenesis
If got ?? can put enamel matrix (Emdogain) on root surface then cover it up again with bone.
Induces ? then new ? and ?? formed leading to ?
bone loss
cementogenesis
PDL
alveolar bone
reattachment
