Overview and Summary of Tooth Development Flashcards
1
Q
what is the scientific name for tooth development?
A
odontogenesis
2
Q
when does odontogenesis start?
A
6 weeks
3
Q
what structure initiates tooth development?
A
epithelium
Then interaction between ectomesenchyme and epithelium
4
Q
remember
For tooth development to occur need both the epithelium and ectomesenchyme
A
5
Q
Need ? and ? to switch genes on for tooth development
A
msx1 and 2
6
Q
what stage of tooth development?
A
bud stage
7
Q
what stage of tooth development?
A
cap stage
8
Q
A
cap stage
9
Q
A
bell stage
10
Q
A
crown stage
11
Q
A
crown stage
12
Q
A
crown stage
13
Q
A
late bell stage
14
Q
when is the bud stage?
A
week 8
15
Q
when is the cap stage?
A
week 11
16
Q
when is the bell stage?
A
week 14
17
Q
A
enamel organ
18
Q
A
dental papilla
19
Q
A
dental lamina
20
Q
remember
A
21
Q
remember
A
22
Q
A
dental follicle
23
Q
A
enamel organ
24
Q
A
outer enamel epithelium
25
stellate reticulum
26
stratum intermedium
27
inner enamel epithelium
28
dental papilla
29
odontoblasts
30
predentine
31
ameloblasts
32
where in the developing tooth is the dentine first layed down?
cusps
as closer to enamel knot so more growth factors etc.
33
where does signalling come from for initiation?
epithelium
34
what genes are in initiation?
BMP
FGF/EGF?
MSX
Shh
35
where does signalling come from for the bud stage?
ectomesenchyme
36
signalling from the ectomesenchyme in the bud stage results in what?
proliferation/condensation
37
what genes are involved in the bud stage?
BMP 2-4
DIX
Syndecan
Tenascin
38
where does signalling come from for the cap stage?
enamel knot (epithelium)
39
signalling from the enamel knot in the cap stage results in what?
proliferation, differentiation and morphogenesis
40
what genes are involved in the cap stage?
collagen
dix 1-3
41
what determines which teeth will develop where? (general)
transcription factors
42
which transcription factors determine which tooth will develop where? 5
MSX-1, MSX-2, DIX1/2, Barx-1, Alx-3
43
teeth only form in specific areas due to transcription factors. name 3?
pitx2
shh
wnt
44
what does Shh do?
increase cell proliferation
only in dental epithelium
45
what does wnt do?
arrests tooth development
46
47
