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4 Craniofacial biology > Tooth Development 1 > Flashcards

Tooth Development 1 Flashcards

1
Q

what is odontogenesis?

A

process of tooth development

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2
Q

what is histogenesis?

A

differentiation of cells to make new tissues

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3
Q

name the mineralised dental tissues

A

enamel, dentine and cementum

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4
Q

name this unmineralised dental tissues?

A

dental pulp and periodontium

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5
Q

what does the vestibular lamina do?

A

contributes to the vestibule of the mouth and delineates the lips and cheek from the teeth formation of sulcus

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6
Q

describe the outer enamel epithelium

A

outer layer of cuboidal cells that limits the enamel organ

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7
Q

describe the stellate reticulum

A

group of cells in the enamel organ
Epithelial origin but some mesenchymal characteristics e.g. collagen I,II&III synthesis

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8
Q

describe the stratum intermedium

A

two/three layers of cells that sit above the inner enamel epithelium

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9
Q

describe the inner enamel epithelium

A

columnar shaped cells rich in RNA connected together by desmosomes

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10
Q

what does the dental lamina do?

A

define where the tooth germ will be

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11
Q

name the stages in tooth development

A

initiation stage
bud stage
cap stage
bell stage
crown stage (also called last bell stage)

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12
Q

preparation before teeth can be formed

? has ? migrating into it -> week ?

Condensation of ectomesenchyme in response to ?

primary ? band being formed

Gives rise to ?? and ??

A

mesenchyme
ectomesenchyme
6

FGF8

epithelial

dental lamina
vestibular lamina

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13
Q

preparation before teeth can be formed

Formation of the ? (vestibule) weeks ?

?? grows into ? weeks ? and ?

Then ? -> weeks ?

Forms ? between the teeth and ??

A

sulcus
7-12

vestibular lamina
mesenchyme
7
8

breaks down
11-12

vestibule
cheeks/lips

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14
Q

tooth development involves an interaction between what?

A

epithelium - ectoderm
mesenchym - ectomesenchyme

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15
Q

in tooth development what does the epithelium (Ectoderm) give rise to?

A

enamel and hyaline layer of the root

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16
Q

in tooth development what does the mesenchyme (Ectomesenchyme) give rise to?

A

dentine, pulp, cementum and periodontium (PDL and bone)

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17
Q

what initiates tooth development?

A

epithelium

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18
Q
A

dental lamina

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19
Q
A

primary epithelial band

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20
Q
A

vestibular lamina

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21
Q

what week is this?

A

week 7

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22
Q

what week is this?

A

week 8

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23
Q

whats happening here?

A

cell death

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24
Q

what week is this?

A

week 11

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25
what week is this?
week 12
26
enamel organ
27
dental papilla
28
dental lamina
29
when is the initiation stage?
week 6
30
when is the bud stage?
week 8
31
what happens in the bud stage?
initiation of epithelial proliferation into the mesenchyme causing the mesenchyme to condense into a ball (bud)
32
when is the cap stage?
week 11
33
what happens in the cap stage?
epithelial migration and proliferation within the mesenchyme to surround the condensed ectomesenchyme
34
when is the bell stage?
week 14
35
what happens in the bell stage? 4
dental lamina shrinks and degrades inner ectomesenchyme -> dental papilla outer ectomesenchyme -> dental follicle enamel organ has 4 distinct layers
36
when is the dental lamina removed from the source? what does this leave behind?
week 17 Cell nests and cell rests which have cystic potential
37
what happens in the crown stage?
Hard tissue formation -> dentine and enamel
38
what are the 4 layers of the enamel organ from outer to innermost
outer enamel epithelium stellate reticulum stratum intermedium inner enamel epithelium
39
stellate reticulum
40
stratum intermedium
41
dental follicle
42
inner enamel epithelium
43
outer enamel epithelium
44
dental lamina
45
dental papilla
46
Inner enamel epithelium forms ?? which will conform to ? ? cells at cusp tips that form ?
basal lamina ADJ columnar ameloblasts -> enamel
47
what does the stratum intermedium do?
Synthesis and transport stuff for the inner enamel epithelium e.g. matrix growth factors
48
Stellate reticulum ? shaped due to ? Role in ?
star desmosomes maintenance of shape and protection
49
Outer enamel epithelium ? cells Role to
cuboidal maintain shape and allow exchange between ectomesenchyme and enamel organ
50
what stage of tooth germ is this?
bud stage
51
What stage is this?
cap stage
52
cap stage
53
bell stage
54
late bell stage
55
crown stage
56
crown stage
57
crown stage
58
what is this?
Enamel knot Area of developing enamel that is a signal centre
59
what is this?
Enamel niche When dental lamina breaks down seen as a hole or depression
60
what is this?
Enamel septum Forms between the outer and inner epithelial cells, aids the change in shape from cap to bell stage
61
what controls the initiation stage of tooth development?
epithelial signalling of growth factors that act on mesenchyme SHH, BMP4 and FGF8
62
what controls the bud stage of tooth development?
mesenchymal signalling of growth factors that act on epithelium Msx1, Pax9 and Bmp4
63
what controls the cap stage of tooth development?
enamel knot signalling that acts on mesenchyme and epithelium FGF4/9 and BMP4/2
64
what does the extracellular matrix do in tooth development?
Allows growth factors to bind, switch on and release Allows cell adhesion, proliferation, migration, polarisation and differentiation
65
name some important matrix molecules
Type I, III, IV collagen, laminin and other proteoglycans - syndecan and tenascin
66
why are these matrix molecules important? Type I, III, IV collagen, laminin and other proteoglycans - syndecan and tenascin
they ensure an intact membrane which is needed for mesenchyme and odontoblasts to bind to it so they can differentiate
67
name a cytokine important in tooth development
BMP4
68
understand this overview

4 Craniofacial biology (20 decks)

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