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4 Craniofacial biology > Tooth Development 2 > Flashcards

Tooth Development 2 Flashcards

1
Q

when is this?

A

week 14

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2
Q
A

stellate reticulum

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3
Q
A

stratum intermedium

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4
Q
A

dental follicle

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5
Q
A

inner enamel epithelium

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6
Q
A

outer enamel epithelium

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7
Q
A

dental lamina

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8
Q
A

dental papilla

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9
Q

name two main things that happen in the bell stage

A

Odontoblasts form predentine
Cervical loop proliferation

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10
Q

bell stage - cervical loop proliferation

where the ? cells meet the ? cells

Signals from the ? induces ? of the ?, as these cells mature get differentiation into ?

Once ? cells mature they signal ? cells to mature and lay down ? then ?

These signal back to the ? for the ? to mature into ? and start laying down ?

A

outer enamel epithelial
inner enamel epithelial

dental papilla (ectomesenchyme)
proliferation
inner enamel epithelium
preameloblasts

IEE
dental papilla
predentine
dentine

IEE
pre-ameloblasts
ameloblasts
enamel

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11
Q

what signals from the dental papilla (ectomesenchyme) induces proliferation of the inner enamel epithelium? 4

A

Bone morphogenic protein
FGF
Wnt
Sonic headgehog

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12
Q
A

odontoblasts

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13
Q
A

predentine

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14
Q
A

preameloblasts

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15
Q
A

dental papilla

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16
Q
A

inner enamel epithelium

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17
Q
A

stratum intermedium

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18
Q
A

sellate reticulum

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19
Q
A

outer enamel epithelium

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20
Q
A

dental follicle

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21
Q

in what stage does enamel start to form?

A

crown stage

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22
Q

in what stage does predentine start to form?

A

bell stage

23
Q
A

ameloblast

24
Q
A

stratum intermedium

25
Q
A

stellate reticulum

26
Q

notice the change in shape of an ameloblast

A
27
Q

give an overview of what happens to an ameloblast as it matures

A

lengthens
develops tomes process
shortens

28
Q

Tooth shape determination - morphogenesis

Takes place in ? stage or ? stage

Tooth shape is determined by differential rates of ?/? through signals from the ?

Happens from the switching on of specific growth factors

A

late bell
early cap

cell division
maturation
dental papilla

29
Q

? drives initiation of tooth development, if its not switched on no teeth will develop

A

PITX2

30
Q

tooth shape determination happens from the switching on of which specific growth factors?

A

Msx1, Msx2, Dlx1, Dlx2, Barx-1 and Alx-3

31
Q

what growth factor stops tooth morphogenesis?

A

Wnt

32
Q

Reduced enamel epithelium

Formed when the 4 layers of enamel organ ? once the crown is ?

Secretes ? that facilitate the breakdown of the ? to form an ?

Interacts with ? to recruit ? that differentiate into ? and can assist connective tissue ? and bone ?

A

fuse
complete

proteases
connective tissue
eruption pathway

dental follicle
monocytes
osteoclasts
degradation
resorption

33
Q

what are the 3 roles of reduced enamel epithelium?

A

protection of enamel surface from resorption and cementum formation

provide an epithelial lined pathway for eruption

forms initial junctional epithelium

34
Q

understand this

A
35
Q

what is a successional dental lamina?

A

formation of secondary dentition behind the primary one

36
Q

where does a successional dental lamina normally form in relation to the primary tooth?

A

Normally goes to the lingual side of the tooth
Tooth gland lamina - if it goes to the labial side

37
Q

successional dental lamina

A
38
Q

what is hypodontia?

A

missing teeth

39
Q

what genes are impacted in hypodontia?

A

msx1 and pax9

40
Q

what is oligodontia?

A

more than 6 teeth missing

41
Q

what genes are impacted in oligodontia?

A

msx1, pax9 and Axin2

42
Q

what is anodontia?

A

all teeth are missing

43
Q

what causes supernumery teeth?

A

overexpression of genes

44
Q

hypodontia, oligodontia, anadontia and supernumeries are caused by developmental disruption in which stage?

A

initiation stage

45
Q

what is microdontia?

A

small teeth

46
Q

what is macrodontia

A

large teeth

47
Q

microdontia and macrodontia are cause by developmental disruption in which stage?

A

bud stage

48
Q

what is dens en dente?

A

enamel organ invaginates into the dental papilla

49
Q

what is this an example of?

A

dense en dente

50
Q

what is gemination?

A

tooth germ tries to divide so get a single root with two teeth

51
Q

how can you tell clinically if its gemination or fusion?

A

fusion may have extra roots

in gemination there will be an extra tooth where as fusion will be a missing tooth

52
Q

dense en dente, fusion and gemination are caused by developmental disruption in which stage?

A

cap stage

53
Q
A

4 Craniofacial biology (20 decks)

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