Tooth Development 2

Question 1

when is this?

Answer 1

week 14

Question 2

Answer 2

stellate reticulum

Question 3

Answer 3

stratum intermedium

Question 4

Answer 4

dental follicle

Question 5

Answer 5

inner enamel epithelium

Question 6

Answer 6

outer enamel epithelium

Question 7

Answer 7

dental lamina

Question 8

Answer 8

dental papilla

Question 9

name two main things that happen in the bell stage

Answer 9

Odontoblasts form predentine
Cervical loop proliferation

Question 10

bell stage - cervical loop proliferation

where the ? cells meet the ? cells

Signals from the ? induces ? of the ?, as these cells mature get differentiation into ?

Once ? cells mature they signal ? cells to mature and lay down ? then ?

These signal back to the ? for the ? to mature into ? and start laying down ?

Answer 10

outer enamel epithelial
inner enamel epithelial

dental papilla (ectomesenchyme)
proliferation
inner enamel epithelium
preameloblasts

IEE
dental papilla
predentine
dentine

IEE
pre-ameloblasts
ameloblasts
enamel

Question 11

what signals from the dental papilla (ectomesenchyme) induces proliferation of the inner enamel epithelium? 4

Answer 11

Bone morphogenic protein
FGF
Wnt
Sonic headgehog

Question 12

Answer 12

odontoblasts

Question 13

Answer 13

predentine

Question 14

Answer 14

preameloblasts

Question 15

Answer 15

dental papilla

Question 16

Answer 16

inner enamel epithelium

Question 17

Answer 17

stratum intermedium

Question 18

Answer 18

sellate reticulum

Question 19

Answer 19

outer enamel epithelium

Question 20

Answer 20

dental follicle

Question 21

in what stage does enamel start to form?

Answer 21

crown stage

Question 22

in what stage does predentine start to form?

Answer 22

bell stage

Question 23

Answer 23

ameloblast

Question 24

Answer 24

stratum intermedium

Question 25

Answer 25

stellate reticulum

Question 26

notice the change in shape of an ameloblast

Question 27

give an overview of what happens to an ameloblast as it matures

Answer 27

lengthens develops tomes process shortens

Question 28

Tooth shape determination - morphogenesis Takes place in ? stage or ? stage Tooth shape is determined by differential rates of ?/? through signals from the ? Happens from the switching on of specific growth factors

Answer 28

late bell early cap cell division maturation dental papilla

Question 29

? drives initiation of tooth development, if its not switched on no teeth will develop

Answer 29

PITX2

Question 30

tooth shape determination happens from the switching on of which specific growth factors?

Answer 30

Msx1, Msx2, Dlx1, Dlx2, Barx-1 and Alx-3

Question 31

what growth factor stops tooth morphogenesis?

Answer 31

Wnt

Question 32

Reduced enamel epithelium Formed when the 4 layers of enamel organ ? once the crown is ? Secretes ? that facilitate the breakdown of the ? to form an ? Interacts with ? to recruit ? that differentiate into ? and can assist connective tissue ? and bone ?

Answer 32

fuse complete proteases connective tissue eruption pathway dental follicle monocytes osteoclasts degradation resorption

Question 33

what are the 3 roles of reduced enamel epithelium?

Answer 33

protection of enamel surface from resorption and cementum formation provide an epithelial lined pathway for eruption forms initial junctional epithelium

Question 34

understand this

Question 35

what is a successional dental lamina?

Answer 35

formation of secondary dentition behind the primary one

Question 36

where does a successional dental lamina normally form in relation to the primary tooth?

Answer 36

Normally goes to the lingual side of the tooth Tooth gland lamina - if it goes to the labial side

Question 37

successional dental lamina

Question 38

what is hypodontia?

Answer 38

missing teeth

Question 39

what genes are impacted in hypodontia?

Answer 39

msx1 and pax9

Question 40

what is oligodontia?

Answer 40

more than 6 teeth missing

Question 41

what genes are impacted in oligodontia?

Answer 41

msx1, pax9 and Axin2

Question 42

what is anodontia?

Answer 42

all teeth are missing

Question 43

what causes supernumery teeth?

Answer 43

overexpression of genes

Question 44

hypodontia, oligodontia, anadontia and supernumeries are caused by developmental disruption in which stage?

Answer 44

initiation stage

Question 45

what is microdontia?

Answer 45

small teeth

Question 46

what is macrodontia

Answer 46

large teeth

Question 47

microdontia and macrodontia are cause by developmental disruption in which stage?

Answer 47

bud stage

Question 48

what is dens en dente?

Answer 48

enamel organ invaginates into the dental papilla

Question 49

what is this an example of?

Answer 49

dense en dente

Question 50

what is gemination?

Answer 50

tooth germ tries to divide so get a single root with two teeth

Question 51

how can you tell clinically if its gemination or fusion?

Answer 51

fusion may have extra roots in gemination there will be an extra tooth where as fusion will be a missing tooth

Question 52

dense en dente, fusion and gemination are caused by developmental disruption in which stage?

Answer 52

cap stage

Question 53