Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Behavioral Pharmacology > Ch 13: Nicotine and Caffeine > Flashcards

Ch 13: Nicotine and Caffeine Flashcards

(66 cards)

Start Studying
1
Q

adenosine

A

Blockade of receptors for this substance is responsible for caffeine’s stimulant effects; serves a neurotransmitter-like function in the brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

caffeinism

A

Syndrome caused by taking excessive amounts of caffeine and characterized by restlessness, insomnia, anxiety, and physiological disturbances.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

chronic obstructive pulmonary disease

A

Disorder of the respiratory system characterized by shortness of breath, wheezing, chronic coughing, and chest tightness. Two main conditions comprise COPD, namely emphysema and bronchitis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

cotinine

A

Principal product of nicotine metabolism by the liver; 70-80% is transformed into this

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

cytochrome P450 2A6

A

Specific type of cytochrome P450 that metabolizes nicotine into cotinine.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

deprivation reversal model

A

Theory that smoking is maintained by mood enhancement (alleviation of irritability, stress) and increased concentration that occur when nicotine withdrawal symptoms are alleviated; proposes that smoking increases overall stress which must be countered by repeated smoking

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

mecamylamine

A

Drug that is an antagonist for nicotinic receptors; blocks action of residual nicotine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

nicotine replacement

A

Method to stop smoking that involves giving the smoker a safer nicotine source, thereby maintaining a level of nicotine in the body and reducing nicotine withdrawal symptoms; chewing gum (nicotine polacrilex) is absorbed in the mouth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

nicotine resource model

A

Theory that smoking is maintained due to positive effects of nicotine such as increased concentration and greater mood control.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

nicotinic cholinergic receptors (nAChRs)

A

Family of ionotropic receptors that are activated by ACh and selectively stimulated by nicotine. They may also be called nicotinic receptors; ionotropic receptors comprising five separate protein units

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

osmotic minipump

A

Device placed just under the skin of an animal that allows a drug to be administered continuously over a set period of time.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

tar

A

Mixture of hydrocarbons created by the vaporization of nicotine in tobacco. Tar is a major component of cigarette smoke.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

nicotine

A

alkaloid found in tobacco leaves; large leaf (Nicotiana tabacum), small leaf (Nicotiana rustica); large leaf is what is used today; 5% of drug tobacco leaves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

amount of nicotine in a typical cigarette

A

6 and 11 mg; no more than 1-3 mg actually reaches the blood stream; enters lungs via tar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

entry of nicotine into the brain

A

reaches in about 7 seconds; smoking is the quickest and most efficient method of delivering nicotine to the brain; arterial nicotine rises more rapidly and reaches a greater peak than in venous blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

excretion of nicotine and related metabolites

A

urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

are there protective effects against cigarette smoking?

A

slow breakdown of nicotine (low CYP2A6 activity)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what does normal levels of CYP2A6 activity and variation in a gene cluster that codes for subunits of the nicotinic cholinergic receptor play a role in?

A

what contributes to smoking frequency, risk for lung cancer, and nicotine dependence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

half life of nicotine

A

2 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

which receptors are more sensitive to nicotine?

A

neuronal receptors containing two alpha4 or alpha3 subunits along with the beta subunits are much more sensitive to nicotine than those composed of five alpha7 subunits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

where are nicotinic cholingeric receptors found?

A

cerebral cortex, thalamus, striatum, hippocampus, monoamine-containing nuclei (substantia nigra; ventral tegmental area; locus coeruleus; raphe nuclei)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

cause of nicotine poisioning

A

high doses of nicotine lead to a persistent activation of nicotinic receptors and a continuous depolarization of the postsynaptic cell. this causes a depolarization block and the cell cant fire again until the nicotine is removed–biphasic effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

mood effects of nicotine

A

increase calmness and relaxation and reduction in negative affect in smokers (relief from nicotine withdrawal); tension, lightheadedness, dizziness, nausea (non smokers)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

calming effect in smokers

A

little difference between nicotine-containing and denicotinized cigarettes in any of these conditions–> conditioned stimuli associated with smoking play a significant role in the calming effects of this behavior in regular smokers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
nicotine and cognitive function
enhanced performance on many cognitive and motor tasks (attentional demands)--> alleviation of withdrawal effects; improvements in find motor performance, accuracy and response latency in certain types of attentional and memory tasks; animals (sustained attention/working memory)
26
use of 5-choice serial reaction time task and cognitive function in mice using nicotine
improved performance with either acute or chronic nicotine administration, but poorer performance during withdrawal from chronic nicotine
27
what nicotine receptors are important in enhanced cognitive function?
nicotinic receptors containing alpha7 subunits
28
mesolimbic dopamina pathway and nicotine's reinforcing effects
VTA to nucleus accumbens; high affinity nicotinic receptors located in the VTA stimulate the firing of DA neurons, which causes increased DA release in the nucleus accumbens; lesioning the dopaminergic innervation of this area with 6-hydroxydopamine (6 OHDA) significantly attenuated nicotine self-administration
29
what nicotine receptors play a role in its rewarding effect?
VTA nicotinic receptors containing alpha6 and beta2 subunits; receptors in the nucleus accumbens contribue to reinforcement by modulating DA release
30
what receptor reduces nicotine self-administration?
alpha5 receptors in the medial habenula (posterior dorsal thalamus)
31
what does nicotine inhibit in the brain?
monoamine oxidase (MAO) A and B in the brain and the periphery; MAO breaks down DA--> may contribute to reinforcing effects
32
physiological effects of nicotine
activates sympathetic and parasympathetic systems; stimulates release of epinephrine and norepinephrine; increased heart rate, elevated blood pressure, increased hydrochloric acid secretion in the stomach (ulcers); increased muscle contraction in the bowel (chronic diarrhea)
33
Can nicotine be toxic?
Yes--60mg can be fatal.
34
symptoms of nicotine poisioning
nausea, excessive salivation, abdominal pain, vomiting, diarrhea, cold sweat, headache, dizziness, disturbed hearing/ vision, mental confusion, marked weakness--> fainting, falling blood pressure, difficulty breathing, weakening of the pulse, rapid/irregular pulse, collapse--> convulsions, respiratory failure
35
acute nicotine tolerance
short lived; smokers undergo a significant degree of nicotine tolerance during the course of the day; after an overnight period of abstinence, smokers awaken the next morning more sensitive to nicotine than at the end of the previous day
36
receptors associated with acute nicotine tolerance
related to desensitization of central nicotinic receptors; receptors composed of BOTH alpha and beta subunits are desensitized at lower nicotine concentrations than alpha7-containing receptors; alpha5beta2 receptors recover more rapidly than alpha7 receptors
37
chronic tolerance
long term nicotine tolerance; elicits a compensatory response manifested by an up-regulation of high-affinity nicotinic receptor expression in many parts of the brain
38
nicotine abstinence syndrome
mediated by a combination of reduced DA activity in the nucleus accumbens and increased corticotropin-releasing factor (CRF) activity in the central nucleus of the amygdala
39
Gender and nicotine
women smoke fewer cigarettes per day, prefer cigarettes with less nicotine, don't inhale as deeply, more influenced by nonnicotine aspects of smoking, find it more difficult to quit
40
does smoking as an adolescent lead to adult smoking?
early smoking increases the chances of smoking as an adult; 1/2 of all people who begin smoking during adolescence and continue with long-term smoking die prematurely from their habit
41
Chippers
smokers who maintain a pattern of regular smoking of a new cigarettes a day without showing the typical signs of dependence
42
what does the relaxing effect of smoking do to a smoker?
brings the smoker to the same state as a typical nonsmoker; first cigarette of the day may elevate mood, but later in the day the peaks in plasma nicotine level only maintain neutral mood
43
what is being a smoker associated with?
increased stress, depressed mood
44
what signifies onset of nicotine dependence (in adolescence)?
loss of autonomy over tobacco use--diminution of the individual's ability to control their smoking behavior
45
what characterizes abstinence syndrome?
tobacco craving, irritability, impatience, restlessness, anxiety, insomnia, difficulty concentrating, hunger, weight gain
46
how long does abstinence syndrome last?
average levels of most symptoms (other than hunger and weight gain) were at or near baseline levels at 4 weeks
47
what other factors, besides nicotine, play a role in smoking?
sensory stimuli associated with smoking (taste/smell) become conditioned to the reinforcing effects of nicotine; knowledge of upcoming opportunities to smoke
48
behavioral interventions for nicotine
antismoking ads, warnings on cigarette packages, high taxes
49
is over the counter nicotine replacement effective?
without additional supportive therapy--not really
50
drugs to help quit smoking
bupropion (originally an antidepressant); varenicline (chantix)--partial agonist at high affinity alpha4beta2 receptors in the VTA
51
major source of caffeine?
coffee beans from the plant coffea arabica; tea leaves have caffeine and theophylline
52
pharmacology of caffeine
absorbed from the GI tract in 30-60 mins; begins in stomach but takes place mainly in the small intestine; half life of 4 hours; almost all its excreted through urine after being converted into metabolites in the liver
53
biphasic behavioral effects of caffeine
low dose has a stimulating effects (increased locomotor activity); high dose animals show reduced activity and humans show tension and anxiety/ panic attacks
54
positive subjective effects of caffeine
feelings of well-being, enhanced energy/ vigor, increased alertness and ability to concentrate, self-confidence, increased work motivation, enhanced sociability; these may be due to alleviation of withdrawal
55
can you be dependent on caffeine?
yes-- it can lead to dependence and abstinence related withdrawal symptoms
56
caffeine and sports
benefits in endurance sports and high intensity activities perhaps by increased force of muscle contraction, enhanced arousal and alertness, and reduced pain perception
57
chronic caffeine use
tolerance to some subjective effects; disruption of sleep; tolerance to the cardiovascular and respiratory effects; headache, fatigue
58
caffeine withdrawal symptoms
headache, drowsiness, fatigue, impaired concentration, psychomotor performance, mild anxiety/ depression
59
acute caffeine administration
leads to several effects on peripheral physiology, including increased blood pressure and respiration rate, enhanced water excretion, and stimulation of catecholamine release from the adrenal medulla
60
chronic ingestion of excessive caffeine
1000mg or more per day; can lead to caffeinism
61
medical uses of caffeine
mild analgesic effects; treatment of newborn infants suffering from apneic episodes (periodic cessation of breathing); treatment of asthma, type 2 diabetes, some neurodegenerative disorders (parkinson's, alzheimer's)
62
mechanisms of action for caffeine
blockade of GABAa receptors, stimulation of Ca2+ release within cells, blockade of A1 and A2a receptors for adenosine
63
what does blockage of receptors for adenosine do?
underlines caffeine-induced behavioral stimulation
64
adenosine and caffeine's effects
it can be released into the brain extracellular fluid, where it acts on several different types of specific adenosine receptors in nerve cell membranes. Four receptor subtypes (A1, A2a, A2b, A3). A1 and A2a are responsible for mediating most of adenosine's effects in the brain--> major receptor for caffeine
65
adenosine and sleep
is a key neurotransmitter/ neuromodulator in sleep production; caffeine promotes arousal--> antagonism of A1 receptor, studies on mice also implicate A2a
66
adenosine and behavioral effects of caffeine
antagonism of A1 and A2a receptors in the striatum where adenosine interacts with DA to modulate locomotor activity

Behavioral Pharmacology (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions