Chapter 15: Hallucinogens, PCP, and Ketamine Flashcards Preview

Behavioral Pharmacology > Chapter 15: Hallucinogens, PCP, and Ketamine > Flashcards

Flashcards in Chapter 15: Hallucinogens, PCP, and Ketamine Deck (80)
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1

Altered States of Consciousness (ASC) rating scale

Psychometric scale developed to quantify the subjective effects of hallucinogenic agents.

2

dimethyltryptamine (DMT)

Hallucinogenic drug found in several South American plants.

3

dissociative anesthesia

An unusual type of anesthetic state characterized by environmental detachment. It is produced by certain noncompetitive NMDA receptor antagonists such as ketamine and PCP.

4

flashback

Reexperience of the perceptual drug effects, specifically those of a hallucinogen, following termination of drug use; when flashbacks occur a long time after prior drug use and are intense the individual is experiencing hallucinogen persisting perception disorder (HPPD)--not common

5

Hallucinogen Rating Scale

Psychometric scale developed to quantify the subjective effects of hallucinogenic agents.

6

indoleamines

Indole derivatives containing an amine group. They include serotonin and the hallucinogens LSD, psilocybin, psilocin, DMT, and 5-MeO-DMT.

7

ketamine

Drug that binds to the PCP site and acts as a noncompetitive antagonist of the NMDA receptor. It is a dissociative anesthetic used in both human and veterinary medicine, and it is also used recreationally.

8

lysergic acid diethylamide (LSD)

Hallucinogenic drug that is synthesized from lysergic acid and based on alkaloids found in ergot fungus. It is thought to produce its effects mainly by stimulating 5-HT2A receptors in the brain.

9

mescal button

Crown of the peyote cactus, Lophophora williamsii, which can be dried and ingested to obtain the hallucinogenic drug mescaline; chewed or cooked raw or extracted as a pure powder.

10

mescaline

Hallucinogenic drug produced by several cacti species, especially that of the peyote cactus, Lophophora williamsii.

11

5-methoxy-dimethyltryptamine (5-MeO-DMT)

Hallucinogenic drug found in certain South American plants. Its street name is “foxy” or “foxy methoxy.”

12

para-chlorophenylalanine (PCPA)

Drug that irreversibly inhibits tryptophan hydroxylase, blocking 5-HT synthesis.

13

peyote button

Species of cactus, Lophophora williamsii, that produces mescaline.

14

phencyclidine (PCP)

Drug that binds to the PCP site and acts as a noncompetitive antagonist of the NMDA receptor. It is a dissociative anesthetic that was once used medicinally but is now only taken recreationally.

15

phenethylamine

Class of drugs that includes mescaline as well as NE- and amphetamine-related substances.

16

psilocin

Metabolite of psilocybin. Psilocin is the actual psychoactive agent.

17

psilocybin

Hallucinogenic drug found in several mushroom species; take 1-5g for effect.

18

psychedelic

Substance that alters perceptions, state of mind or awareness; "mind-opening"

19

psychedelic therapy

Therapeutic method that involved giving patients a single high dose of LSD to help them understand their problems by reaching a drug-induced spiritual state.

20

psychotomimetic

Substance that mimics psychosis in a subject, such as by inducing hallucinations or delusions.

21

salvinorin A

Active compound in the hallucinogenic plant Salvia divinorum; acts as a κ-opioid receptor agonist.

22

synesthesia

Mixing of sensations such that one kind of sensory stimulus creates a different kind of sensation, such as a color producing the sensation of sound.

23

hallucinogens

substances whose primary effect is to cause perceptual and cognitive distortions without producing a state of toxic delerium

24

what happens to psilocybin when ingested?

it is enzymatically converted to psilocin, which is the actual psychoactive component

25

ayahuasca

hallucinogenic brew from stalks and leaves containing DMT and vines containing several types of alkaloids called beta-carbolines, which are known to inhibit the enzyme MAO

26

synthetic DMT analogs

AMT and Foxy

27

how is DMT and 5-MeO-DMT taken?

it is found in a number of plans and is typically turned into a drink

28

is LSD natural?

no it is synthetic

29

analeptics

circulatory and respiratory stimulants

30

psycholytic therapy

based on the concept of drug-induced psycholysis--meaning psychic loosening or opening. Involved giving LSD in low but gradually increasing doses to promote the release of repressed memories and to enhance communication.